Uroporphyrinogen-III synthase (UROIIIS) (UROS) (EC 4.2.1.75) (Hydroxymethylbilane hydrolyase [cyclizing]) (Uroporphyrinogen-III cosynthase)
1_MKVLL 6_ LKDAK 11_ EDDCG 16_ QDPYI 21_ RELGL 26_ YGLEA 31_ TLIPV 36_ LSFEF 41_ LSLPS 46_ FSEKL 51_ SHPED 56_ YGGLI 61_ FTSPR 66_ AVEAA 71_ ELCLE 76_ QNNKT 81_ EVWER 86_ SLKEK 91_ WNAKS 96_ VYVVG 101_ NATAS 106_ LVSKI 111_ GLDTE 116_ GETCG 121_ NAEKL 126_ AEYIC 131_ SRESS 136_ ALPLL 141_ FPCGN 146_ LKREI 151_ LPKAL 156_ KDKGI 161_ AMESI 166_ TVYQT 171_ VAHPG 176_ IQGNL 181_ NSYYS 186_ QQGVP 191_ ASITF 196_ FSPSG 201_ LTYSL 206_ KHIQE 211_ LSGDN 216_ IDQIK 221_ FAAIG 226_ PTTAR 231_ ALAAQ 236_ GLPVS 241_ CTAES 246_ PTPQA 251_ LATGI 256_RKALQ
1: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III, the branch point for the various sub-pathways leading to the wide diversity of porphyrins (PubMed:11689424, PubMed:18004775). Porphyrins act as cofactors for a multitude of enzymes that perform a variety of processes within the cell such as methionine synthesis (vitamin B12) or oxygen transport (heme) (PubMed:11689424, PubMed:18004775)