Retinoic acid receptor beta (RAR-beta) (HBV-activated protein) (Nuclear receptor subfamily 1 group B member 2) (RAR-epsilon)
1_MTTSG 6_ HACPV 11_ PAVNG 16_ HMTHY 21_ PATPY 26_ PLLFP 31_ PVIGG 36_ LSLPP 41_ LHGLH 46_ GHPPP 51_ SGCST 56_ PSPAT 61_ IETQS 66_ TSSEE 71_ LVPSP 76_ PSPLP 81_ PPRVY 86_ KPCFV 91_ CQDKS 96_ SGYHY 101_ GVSAC 106_ EGCKG 111_ FFRRS 116_ IQKNM 121_ IYTCH 126_ RDKNC 131_ VINKV 136_ TRNRC 141_ QYCRL 146_ QKCFE 151_ VGMSK 156_ ESVRN 161_ DRNKK 166_ KKETS 171_ KQECT 176_ ESYEM 181_ TAELD 186_ DLTEK 191_ IRKAH 196_ QETFP 201_ SLCQL 206_ GKYTT 211_ NSSAD 216_ HRVRL 221_ DLGLW 226_ DKFSE 231_ LATKC 236_ IIKIV 241_ EFAKR 246_ LPGFT 251_ GLTIA 256_ DQITL 261_ LKAAC 266_ LDILI 271_ LRICT 276_ RYTPE 281_ QDTMT 286_ FSDGL 291_ TLNRT 296_ QMHNA 301_ GFGPL 306_ TDLVF 311_ TFANQ 316_ LLPLE 321_ MDDTE 326_ TGLLS 331_ AICLI 336_ CGDRQ 341_ DLEEP 346_ TKVDK 351_ LQEPL 356_ LEALK 361_ IYIRK 366_ RRPSK 371_ PHMFP 376_ KILMK 381_ ITDLR 386_ SISAK 391_ GAERV 396_ ITLKM 401_ EIPGS 406_ MPPLI 411_ QEMLE 416_ NSEGH 421_ EPLTP 426_ SSSGN 431_ TAEHS 436_ PSISP 441_ SSVEN 446_SGVSQ
1: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence or presence of hormone ligand, acts mainly as an activator of gene expression due to weak binding to corepressors (PubMed:12554770). The RXRA/RARB heterodimer can act as a repressor on the DR1 element and as an activator on the DR5 element (PubMed:29021580). In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (By similarity)