Proto-oncogene DBL (Proto-oncogene MCF-2) [Cleaved into: MCF2-transforming protein; DBL-transforming protein]
1_MAEAN 6_ PRRGK 11_ MRFRR 16_ NAASF 21_ PGNLH 26_ LVLVL 31_ RPTSF 36_ LQRTF 41_ TDIGF 46_ WFSQE 51_ DFMLK 56_ LPVVM 61_ LSSVS 66_ DLLTY 71_ IDDKQ 76_ LTPEL 81_ GGTLQ 86_ YCHSE 91_ WIIFR 96_ NAIEN 101_ FALTV 106_ KEMAQ 111_ MLQSF 116_ GTELA 121_ ETELP 126_ DDIPS 131_ IEEIL 136_ AIRAE 141_ RYHLL 146_ KNDIT 151_ AVTKE 156_ GKILL 161_ TNLEV 166_ PDTEG 171_ AVSSR 176_ LECHR 181_ QISGD 186_ WQTIN 191_ KLLTQ 196_ VHDME 201_ TAFDG 206_ FWEKH 211_ QLKME 216_ QYLQL 221_ WKFEQ 226_ DFQQL 231_ VTEVE 236_ FLLNQ 241_ QAELA 246_ DVTGT 251_ IAQVK 256_ QKIKK 261_ LENLD 266_ ENSQE 271_ LLSKA 276_ QFVIL 281_ HGHKL 286_ AANHH 291_ YALDL 296_ ICQRC 301_ NELRY 306_ LSDIL 311_ VNEIK 316_ AKRIQ 321_ LSRTF 326_ KMHKL 331_ LQQAR 336_ QCCDE 341_ GECLL 346_ ANQEI 351_ DKFQS 356_ KEDAQ 361_ KALQD 366_ IENFL 371_ EMALP 376_ FINYE 381_ PETLQ 386_ YEFDV 391_ ILSPE 396_ LKVQM 401_ KTIQL 406_ KLENI 411_ RSIFE 416_ NQQAG 421_ FRNLA 426_ DKHVR 431_ PIQFV 436_ VPTPE 441_ NLVTS 446_ GTPFF 451_ SSKQG 456_ KKTWR 461_ QNQSN 466_ LKIEV 471_ VPDCQ 476_ EKRSS 481_ GPSSS 486_ LDNGN 491_ SLDVL 496_ KNHVL 501_ NELIQ 506_ TERVY 511_ VRELY 516_ TVLLG 521_ YRAEM 526_ DNPEM 531_ FDLMP 536_ PLLRN 541_ KKDIL 546_ FGNMA 551_ EIYEF 556_ HNDIF 561_ LSSLE 566_ NCAHA 571_ PERVG 576_ PCFLE 581_ RKDDF 586_ QMYAK 591_ YCQNK 596_ PRSET 601_ IWRKY 606_ SECAF 611_ FQECQ 616_ RKLKH 621_ RLRLD 626_ SYLLK 631_ PVQRI 636_ TKYQL 641_ LLKEL 646_ LKYSK 651_ DCEGS 656_ ALLKK 661_ ALDAM 666_ LDLLK 671_ SVNDS 676_ MHQIA 681_ INGYI 686_ GNLNE 691_ LGKMI 696_ MQGGF 701_ SVWIG 706_ HKKGA 711_ TKMKD 716_ LARFK 721_ PMQRH 726_ LFLYE 731_ KAIVF 736_ CKRRV 741_ ESGEG 746_ SDRYP 751_ SYSFK 756_ HCWKM 761_ DEVGI 766_ TEYVK 771_ GDNRK 776_ FEIWY 781_ GEKEE 786_ VYIVQ 791_ ASNVD 796_ VKMTW 801_ LKEIR 806_ NILLK 811_ QQELL 816_ TVKKR 821_ KQQDQ 826_ LTERD 831_ KFQIS 836_ LQQND 841_ EKQQG 846_ AFIST 851_ EETEL 856_ EHTST 861_ VVEVC 866_ EAIAS 871_ VQAEA 876_ NTVWT 881_ EASQS 886_ AEISE 891_ EPAEW 896_ SSNYF 901_ YPTYD 906_ ENEEE 911_ NRPLM 916_RPVSE
1: Guanine nucleotide exchange factor (GEF) that modulates the Rho family of GTPases. Promotes the conversion of some member of the Rho family GTPase from the GDP-bound to the GTP-bound form. Isoform 1 exhibits no activity toward RHOA, RAC1 or CDC42. Isoform 2 exhibits decreased GEF activity toward CDC42. Isoform 3 exhibits a weak but significant activity toward RAC1 and CDC42. Isoform 4 exhibits significant activity toward RHOA and CDC42. The truncated DBL oncogene is active toward RHOA, RAC1 and CDC42