Growth hormone receptor (GH receptor) (Somatotropin receptor) [Cleaved into: Growth hormone-binding protein (GH-binding protein) (GHBP) (Serum-binding protein)]
1_MDLWQ 6_ LLLTL 11_ ALAGS 16_ SDAFS 21_ GSEAT 26_ AAILS 31_ RAPWS 36_ LQSVN 41_ PGLKT 46_ NSSKE 51_ PKFTK 56_ CRSPE 61_ RETFS 66_ CHWTD 71_ EVHHG 76_ TKNLG 81_ PIQLF 86_ YTRRN 91_ TQEWT 96_ QEWKE 101_ CPDYV 106_ SAGEN 111_ SCYFN 116_ SSFTS 121_ IWIPY 126_ CIKLT 131_ SNGGT 136_ VDEKC 141_ FSVDE 146_ IVQPD 151_ PPIAL 156_ NWTLL 161_ NVSLT 166_ GIHAD 171_ IQVRW 176_ EAPRN 181_ ADIQK 186_ GWMVL 191_ EYELQ 196_ YKEVN 201_ ETKWK 206_ MMDPI 211_ LTTSV 216_ PVYSL 221_ KVDKE 226_ YEVRV 231_ RSKQR 236_ NSGNY 241_ GEFSE 246_ VLYVT 251_ LPQMS 256_ QFTCE 261_ EDFYF 266_ PWLLI 271_ IIFGI 276_ FGLTV 281_ MLFVF 286_ LFSKQ 291_ QRIKM 296_ LILPP 301_ VPVPK 306_ IKGID 311_ PDLLK 316_ EGKLE 321_ EVNTI 326_ LAIHD 331_ SYKPE 336_ FHSDD 341_ SWVEF 346_ IELDI 351_ DEPDE 356_ KTEES 361_ DTDRL 366_ LSSDH 371_ EKSHS 376_ NLGVK 381_ DGDSG 386_ RTSCC 391_ EPDIL 396_ ETDFN 401_ ANDIH 406_ EGTSE 411_ VAQPQ 416_ RLKGE 421_ ADLLC 426_ LDQKN 431_ QNNSP 436_ YHDAC 441_ PATQQ 446_ PSVIQ 451_ AEKNK 456_ PQPLP 461_ TEGAE 466_ STHQA 471_ AHIQL 476_ SNPSS 481_ LSNID 486_ FYAQV 491_ SDITP 496_ AGSVV 501_ LSPGQ 506_ KNKAG 511_ MSQCD 516_ MHPEM 521_ VSLCQ 526_ ENFLM 531_ DNAYF 536_ CEADA 541_ KKCIP 546_ VAPHI 551_ KVESH 556_ IQPSL 561_ NQEDI 566_ YITTE 571_ SLTTA 576_ AGRPG 581_ TGEHV 586_ PGSEM 591_ PVPDY 596_ TSIHI 601_ VQSPQ 606_ GLILN 611_ ATALP 616_ LPDKE 621_ FLSSC 626_ GYVST 631_DQLNK
1: Receptor for pituitary gland growth hormone (GH1) involved in regulating postnatal body growth (PubMed:1549776, PubMed:2825030, PubMed:8943276). On ligand binding, couples to the JAK2/STAT5 pathway (PubMed:1549776, PubMed:15690087, PubMed:2825030, PubMed:8943276)
2: The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling
3: Up-regulates the production of the soluble Growth hormone-binding protein form (GHBP) and acts as a negative inhibitor of growth hormone signaling