Myosin regulatory light chain 2, ventricular/cardiac muscle isoform (MLC-2) (MLC-2v) (Cardiac myosin light chain 2) (Myosin light chain 2, slow skeletal/ventricular muscle isoform) (MLC-2s/v) (Ventricular myosin light chain 2)
1_MAPKK 6_ AKKRA 11_ GGANS 16_ NVFSM 21_ FEQTQ 26_ IQEFK 31_ EAFTI 36_ MDQNR 41_ DGFID 46_ KNDLR 51_ DTFAA 56_ LGRVN 61_ VKNEE 66_ IDEMI 71_ KEAPG 76_ PINFT 81_ VFLTM 86_ FGEKL 91_ KGADP 96_ EETIL 101_ NAFKV 106_ FDPEG 111_ KGVLK 116_ ADYVR 121_ EMLTT 126_ QAERF 131_ SKEEV 136_ DQMFA 141_ AFPPD 146_ VTGNL 151_ DYKNL 156_ VHIIT 161_HGEEK
1: Contractile protein that plays a role in heart development and function (PubMed:23365102, PubMed:32453731). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin binding sites to sustain thin filament activation as a means to fine-tune myofilament calcium sensitivity to force (By similarity). During cardiogenesis plays an early role in cardiac contractility by promoting cardiac myofibril assembly (By similarity)