Gene name: IAPP

Uniprot entry:

P10997

Protein names:

Islet amyloid polypeptide (Amylin) (Diabetes-associated peptide) (DAP) (Insulinoma amyloid peptide)

Protein sequence:

1_MGILK 6_ LQVFL 11_ IVLSV 16_ ALNHL 21_ KATPI 26_ ESHQV 31_ EKRKC 36_ NTATC 41_ ATQRL 46_ ANFLV 51_ HSSNN 56_ FGAIL 61_ SSTNV 66_ GSNTY 71_ GKRNA 76_ VEVLK 81_REPLN

Protein annotations

Protein functions:

1: Amylin/IAPP is a glucoregulatory peptide hormone that plays an important role in the regulation of energy homeostasis (PubMed:2690069). Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism. IAPP function is mediated by the CALCR-RAMPs (AMYRs) receptor complexes (By similarity). Amylin can also bind CALCR receptor in the absence of RAMPs, although it is more selective for AMYRs (By similarity)