Leukocyte antigen CD37 (Tetraspanin-26) (Tspan-26) (CD antigen CD37)
1_MSAQE 6_ SCLSL 11_ IKYFL 16_ FVFNL 21_ FFFVL 26_ GSLIF 31_ CFGIW 36_ ILIDK 41_ TSFVS 46_ FVGLA 51_ FVPLQ 56_ IWSKV 61_ LAISG 66_ IFTMG 71_ IALLG 76_ CVGAL 81_ KELRC 86_ LLGLY 91_ FGMLL 96_ LLFAT 101_ QITLG 106_ ILIST 111_ QRAQL 116_ ERSLR 121_ DVVEK 126_ TIQKY 131_ GTNPE 136_ ETAAE 141_ ESWDY 146_ VQFQL 151_ RCCGW 156_ HYPQD 161_ WFQVL 166_ ILRGN 171_ GSEAH 176_ RVPCS 181_ CYNLS 186_ ATNDS 191_ TILDK 196_ VILPQ 201_ LSRLG 206_ HLARS 211_ RHSAD 216_ ICAVP 221_ AESHI 226_ YREGC 231_ AQGLQ 236_ KWLHN 241_ NLISI 246_ VGICL 251_ GVGLL 256_ ELGFM 261_ TLSIF 266_ LCRNL 271_ DHVYN 276_RLARY
1: Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Participates thereby in diverse biological functions such as cell signal transduction, adhesion, migration and protein trafficking (PubMed:22624718). Upon ligand binding, two signaling pathways are activated, one acting through phosphorylation by LYN leading to cell death or a survival pathway with activation of GSK3B (PubMed:22624718). Plays an essential role essential for clustering of integrin ITGA4/ITGB1 and promotes its mobility in the plasma membrane of B-cells. In turn, participates in ITGA4/ITGB1 integrin-mediated antiapoptotic signaling through AKT (By similarity). Also plays a role in the migration of dendritic cells and neutrophils to draining lymph nodes, as well as in their integrin-mediated adhesion (By similarity). Negatively regulates IL-6 responses through direct interaction with SOCS3 thereby preventing constitutive IL-6 signaling (PubMed:26784544). Alternatively, inhibition of IL-6 signaling can also occur via interaction and stabilization of DECTIN1/CLEC7A at the cell membrane to inhibit its ability to promote the production of IL-6 (PubMed:17182550)