Gene name: PNMT

Uniprot entry:

P11086

Protein names:

Phenylethanolamine N-methyltransferase (PNMTase) (EC 2.1.1.28) (Noradrenaline N-methyltransferase)

Protein sequence:

1_MSGAD 6_ RSPNA 11_ GAAPD 16_ SAPGQ 21_ AAVAS 26_ AYQRF 31_ EPRAY 36_ LRNNY 41_ APPRG 46_ DLCNP 51_ NGVGP 56_ WKLRC 61_ LAQTF 66_ ATGEV 71_ SGRTL 76_ IDIGS 81_ GPTVY 86_ QLLSA 91_ CSHFE 96_ DITMT 101_ DFLEV 106_ NRQEL 111_ GRWLQ 116_ EEPGA 121_ FNWSM 126_ YSQHA 131_ CLIEG 136_ KGECW 141_ QDKER 146_ QLRAR 151_ VKRVL 156_ PIDVH 161_ QPQPL 166_ GAGSP 171_ APLPA 176_ DALVS 181_ AFCLE 186_ AVSPD 191_ LASFQ 196_ RALDH 201_ ITTLL 206_ RPGGH 211_ LLLIG 216_ ALEES 221_ WYLAG 226_ EARLT 231_ VVPVS 236_ EEEVR 241_ EALVR 246_ SGYKV 251_ RDLRT 256_ YIMPA 261_ HLQTG 266_ VDDVK 271_ GVFFA 276_WAQKV

Protein annotations

Protein functions:

1: Catalyzes the transmethylation of nonepinephrine (noradrenaline) to form epinephrine (adrenaline), using S-adenosyl-L-methionine as the methyl donor (PubMed:20496117). Other substrates include phenylethanolamine and octopamine (PubMed:16277617, PubMed:16363801, PubMed:8812853). Also methylates normetanephrine (By similarity)