Hepatic triacylglycerol lipase (HL) (Hepatic lipase) (EC 3.1.1.3) (Lipase member C) (Lysophospholipase) (EC 3.1.1.5) (Phospholipase A1) (EC 3.1.1.32)
1_MDTSP 6_ LCFSI 11_ LLVLC 16_ IFIQS 21_ SALGQ 26_ SLKPE 31_ PFGRR 36_ AQAVE 41_ TNKTL 46_ HEMKT 51_ RFLLF 56_ GETNQ 61_ GCQIR 66_ INHPD 71_ TLQEC 76_ GFNSS 81_ LPLVM 86_ IIHGW 91_ SVDGV 96_ LENWI 101_ WQMVA 106_ ALKSQ 111_ PAQPV 116_ NVGLV 121_ DWITL 126_ AHDHY 131_ TIAVR 136_ NTRLV 141_ GKEVA 146_ ALLRW 151_ LEESV 156_ QLSRS 161_ HVHLI 166_ GYSLG 171_ AHVSG 176_ FAGSS 181_ IGGTH 186_ KIGRI 191_ TGLDA 196_ AGPLF 201_ EGSAP 206_ SNRLS 211_ PDDAN 216_ FVDAI 221_ HTFTR 226_ EHMGL 231_ SVGIK 236_ QPIGH 241_ YDFYP 246_ NGGSF 251_ QPGCH 256_ FLELY 261_ RHIAQ 266_ HGFNA 271_ ITQTI 276_ KCSHE 281_ RSVHL 286_ FIDSL 291_ LHAGT 296_ QSMAY 301_ PCGDM 306_ NSFSQ 311_ GLCLS 316_ CKKGR 321_ CNTLG 326_ YHVRQ 331_ EPRSK 336_ SKRLF 341_ LVTRA 346_ QSPFK 351_ VYHYQ 356_ FKIQF 361_ INQTE 366_ TPIQT 371_ TFTMS 376_ LLGTK 381_ EKMQK 386_ IPITL 391_ GKGIA 396_ SNKTY 401_ SFLIT 406_ LDVDI 411_ GELIM 416_ IKFKW 421_ ENSAV 426_ WANVW 431_ DTVQT 436_ IIPWS 441_ TGPRH 446_ SGLVL 451_ KTIRV 456_ KAGET 461_ QQRMT 466_ FCSEN 471_ TDDLL 476_ LRPTQ 481_ EKIFV 486_ KCEIK 491_SKTSK
1: Catalyzes the hydrolysis of triglycerides and phospholipids present in circulating plasma lipoproteins, including chylomicrons, intermediate density lipoproteins (IDL), low density lipoproteins (LDL) of large size and high density lipoproteins (HDL), releasing free fatty acids (FFA) and smaller lipoprotein particles (PubMed:12032167, PubMed:26193433, PubMed:7592706, PubMed:8798474). Also exhibits lysophospholipase activity (By similarity). Can hydrolyze both neutral lipid and phospholipid substrates but shows a greater binding affinity for neutral lipid substrates than phospholipid substrates (By similarity). In native LDL, preferentially hydrolyzes the phosphatidylcholine species containing polyunsaturated fatty acids at sn-2 position (PubMed:26193433)