E3 SUMO-protein ligase EGR2 (EC 2.3.2.-) (AT591) (E3 SUMO-protein transferase ERG2) (Early growth response protein 2) (EGR-2) (Zinc finger protein Krox-20)
1_MMTAK 6_ AVDKI 11_ PVTLS 16_ GFVHQ 21_ LSDNI 26_ YPVED 31_ LAATS 36_ VTIFP 41_ NAELG 46_ GPFDQ 51_ MNGVA 56_ GDGMI 61_ NIDMT 66_ GEKRS 71_ LDLPY 76_ PSSFA 81_ PVSAP 86_ RNQTF 91_ TYMGK 96_ FSIDP 101_ QYPGA 106_ SCYPE 111_ GIINI 116_ VSAGI 121_ LQGVT 126_ SPAST 131_ TASSS 136_ VTSAS 141_ PNPLA 146_ TGPLG 151_ VCTMS 156_ QTQPD 161_ LDHLY 166_ SPPPP 171_ PPPYS 176_ GCAGD 181_ LYQDP 186_ SAFLS 191_ AATTS 196_ TSSSL 201_ AYPPP 206_ PSYPS 211_ PKPAT 216_ DPGLF 221_ PMIPD 226_ YPGFF 231_ PSQCQ 236_ RDLHG 241_ TAGPD 246_ RKPFP 251_ CPLDT 256_ LRVPP 261_ PLTPL 266_ STIRN 271_ FTLGG 276_ PSAGV 281_ TGPGA 286_ SGGSE 291_ GPRLP 296_ GSSSA 301_ AAAAA 306_ AAAAY 311_ NPHHL 316_ PLRPI 321_ LRPRK 326_ YPNRP 331_ SKTPV 336_ HERPY 341_ PCPAE 346_ GCDRR 351_ FSRSD 356_ ELTRH 361_ IRIHT 366_ GHKPF 371_ QCRIC 376_ MRNFS 381_ RSDHL 386_ TTHIR 391_ THTGE 396_ KPFAC 401_ DYCGR 406_ KFARS 411_ DERKR 416_ HTKIH 421_ LRQKE 426_ RKSSA 431_ PSASV 436_ PAPST 441_ ASCSG 446_ GVQPG 451_ GTLCS 456_ SNSSS 461_ LGGGP 466_ LAPCS 471_SRTRT
1: Sequence-specific DNA-binding transcription factor (PubMed:17717711). Plays a role in hindbrain segmentation by regulating the expression of a subset of homeobox containing genes and in Schwann cell myelination by regulating the expression of genes involved in the formation and maintenance of myelin (By similarity). Binds to two EGR2-consensus sites EGR2A (5'-CTGTAGGAG-3') and EGR2B (5'-ATGTAGGTG-3') in the HOXB3 enhancer and promotes HOXB3 transcriptional activation (By similarity). Binds to specific DNA sites located in the promoter region of HOXA4, HOXB2 and ERBB2 (By similarity). Regulates hindbrain segmentation by controlling the expression of Hox genes, such as HOXA4, HOXB3 and HOXB2, and thereby specifying odd and even rhombomeres (By similarity). Promotes the expression of HOXB3 in the rhombomere r5 in the hindbrain (By similarity). Regulates myelination in the peripheral nervous system after birth, possibly by regulating the expression of myelin proteins, such as MPZ, and by promoting the differentiation of Schwann cells (By similarity). Involved in the development of the jaw openener musculature, probably by playing a role in its innervation through trigeminal motor neurons (By similarity). May play a role in adipogenesis, possibly by regulating the expression of CEBPB (By similarity)
2: E3 SUMO-protein ligase helping SUMO1 conjugation to its coregulators NAB1 and NAB2, whose sumoylation down-regulates EGR2 transcriptional activity