Uridine 5'-monophosphate synthase (UMP synthase) [Includes: Orotate phosphoribosyltransferase (OPRT) (OPRTase) (EC 2.4.2.10); Orotidine 5'-phosphate decarboxylase (ODC) (OMPD) (EC 4.1.1.23) (OMPdecase)]
1_MAVAR 6_ AALGP 11_ LVTGL 16_ YDVQA 21_ FKFGD 26_ FVLKS 31_ GLSSP 36_ IYIDL 41_ RGIVS 46_ RPRLL 51_ SQVAD 56_ ILFQT 61_ AQNAG 66_ ISFDT 71_ VCGVP 76_ YTALP 81_ LATVI 86_ CSTNQ 91_ IPMLI 96_ RRKET 101_ KDYGT 106_ KRLVE 111_ GTINP 116_ GETCL 121_ IIEDV 126_ VTSGS 131_ SVLET 136_ VEVLQ 141_ KEGLK 146_ VTDAI 151_ VLLDR 156_ EQGGK 161_ DKLQA 166_ HGIRL 171_ HSVCT 176_ LSKML 181_ EILEQ 186_ QKKVD 191_ AETVG 196_ RVKRF 201_ IQENV 206_ FVAAN 211_ HNGSP 216_ LSIKE 221_ APKEL 226_ SFGAR 231_ AELPR 236_ IHPVA 241_ SKLLR 246_ LMQKK 251_ ETNLC 256_ LSADV 261_ SLARE 266_ LLQLA 271_ DALGP 276_ SICML 281_ KTHVD 286_ ILNDF 291_ TLDVM 296_ KELIT 301_ LAKCH 306_ EFLIF 311_ EDRKF 316_ ADIGN 321_ TVKKQ 326_ YEGGI 331_ FKIAS 336_ WADLV 341_ NAHVV 346_ PGSGV 351_ VKGLQ 356_ EVGLP 361_ LHRGC 366_ LLIAE 371_ MSSTG 376_ SLATG 381_ DYTRA 386_ AVRMA 391_ EEHSE 396_ FVVGF 401_ ISGSR 406_ VSMKP 411_ EFLHL 416_ TPGVQ 421_ LEAGG 426_ DNLGQ 431_ QYNSP 436_ QEVIG 441_ KRGSD 446_ IIIVG 451_ RGIIS 456_ AADRL 461_ EAAEM 466_ YRKAA 471_WEAYL
1: Bifunctional enzyme catalyzing the last two steps of de novo pyrimidine biosynthesis, orotate phosphoribosyltransferase (OPRT), which converts orotate to orotidine-5'-monophosphate (OMP), and orotidine-5'-monophosphate decarboxylase (ODC), the terminal enzymatic reaction that decarboxylates OMP to uridine monophosphate (UMP)