Integrin alpha-M (CD11 antigen-like family member B) (CR-3 alpha chain) (Cell surface glycoprotein MAC-1 subunit alpha) (Leukocyte adhesion receptor MO1) (Neutrophil adherence receptor) (CD antigen CD11b)
1_MALRV 6_ LLLTA 11_ LTLCH 16_ GFNLD 21_ TENAM 26_ TFQEN 31_ ARGFG 36_ QSVVQ 41_ LQGSR 46_ VVVGA 51_ PQEIV 56_ AANQR 61_ GSLYQ 66_ CDYST 71_ GSCEP 76_ IRLQV 81_ PVEAV 86_ NMSLG 91_ LSLAA 96_ TTSPP 101_ QLLAC 106_ GPTVH 111_ QTCSE 116_ NTYVK 121_ GLCFL 126_ FGSNL 131_ RQQPQ 136_ KFPEA 141_ LRGCP 146_ QEDSD 151_ IAFLI 156_ DGSGS 161_ IIPHD 166_ FRRMK 171_ EFVST 176_ VMEQL 181_ KKSKT 186_ LFSLM 191_ QYSEE 196_ FRIHF 201_ TFKEF 206_ QNNPN 211_ PRSLV 216_ KPITQ 221_ LLGRT 226_ HTATG 231_ IRKVV 236_ RELFN 241_ ITNGA 246_ RKNAF 251_ KILVV 256_ ITDGE 261_ KFGDP 266_ LGYED 271_ VIPEA 276_ DREGV 281_ IRYVI 286_ GVGDA 291_ FRSEK 296_ SRQEL 301_ NTIAS 306_ KPPRD 311_ HVFQV 316_ NNFEA 321_ LKTIQ 326_ NQLRE 331_ KIFAI 336_ EGTQT 341_ GSSSS 346_ FEHEM 351_ SQEGF 356_ SAAIT 361_ SNGPL 366_ LSTVG 371_ SYDWA 376_ GGVFL 381_ YTSKE 386_ KSTFI 391_ NMTRV 396_ DSDMN 401_ DAYLG 406_ YAAAI 411_ ILRNR 416_ VQSLV 421_ LGAPR 426_ YQHIG 431_ LVAMF 436_ RQNTG 441_ MWESN 446_ ANVKG 451_ TQIGA 456_ YFGAS 461_ LCSVD 466_ VDSNG 471_ STDLV 476_ LIGAP 481_ HYYEQ 486_ TRGGQ 491_ VSVCP 496_ LPRGR 501_ ARWQC 506_ DAVLY 511_ GEQGQ 516_ PWGRF 521_ GAALT 526_ VLGDV 531_ NGDKL 536_ TDVAI 541_ GAPGE 546_ EDNRG 551_ AVYLF 556_ HGTSG 561_ SGISP 566_ SHSQR 571_ IAGSK 576_ LSPRL 581_ QYFGQ 586_ SLSGG 591_ QDLTM 596_ DGLVD 601_ LTVGA 606_ QGHVL 611_ LLRSQ 616_ PVLRV 621_ KAIME 626_ FNPRE 631_ VARNV 636_ FECND 641_ QVVKG 646_ KEAGE 651_ VRVCL 656_ HVQKS 661_ TRDRL 666_ REGQI 671_ QSVVT 676_ YDLAL 681_ DSGRP 686_ HSRAV 691_ FNETK 696_ NSTRR 701_ QTQVL 706_ GLTQT 711_ CETLK 716_ LQLPN 721_ CIEDP 726_ VSPIV 731_ LRLNF 736_ SLVGT 741_ PLSAF 746_ GNLRP 751_ VLAED 756_ AQRLF 761_ TALFP 766_ FEKNC 771_ GNDNI 776_ CQDDL 781_ SITFS 786_ FMSLD 791_ CLVVG 796_ GPREF 801_ NVTVT 806_ VRNDG 811_ EDSYR 816_ TQVTF 821_ FFPLD 826_ LSYRK 831_ VSTLQ 836_ NQRSQ 841_ RSWRL 846_ ACESA 851_ SSTEV 856_ SGALK 861_ STSCS 866_ INHPI 871_ FPENS 876_ EVTFN 881_ ITFDV 886_ DSKAS 891_ LGNKL 896_ LLKAN 901_ VTSEN 906_ NMPRT 911_ NKTEF 916_ QLELP 921_ VKYAV 926_ YMVVT 931_ SHGVS 936_ TKYLN 941_ FTASE 946_ NTSRV 951_ MQHQY 956_ QVSNL 961_ GQRSL 966_ PISLV 971_ FLVPV 976_ RLNQT 981_ VIWDR 986_ PQVTF 991_ SENLS 996_ STCHT 1001_ KERLP 1006_ SHSDF 1011_ LAELR 1016_ KAPVV 1021_ NCSIA 1026_ VCQRI 1031_ QCDIP 1036_ FFGIQ 1041_ EEFNA 1046_ TLKGN 1051_ LSFDW 1056_ YIKTS 1061_ HNHLL 1066_ IVSTA 1071_ EILFN 1076_ DSVFT 1081_ LLPGQ 1086_ GAFVR 1091_ SQTET 1096_ KVEPF 1101_ EVPNP 1106_ LPLIV 1111_ GSSVG 1116_ GLLLL 1121_ ALITA 1126_ ALYKL 1131_ GFFKR 1136_ QYKDM 1141_ MSEGG 1146_PPGAE
1: Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens (PubMed:20008295, PubMed:9558116). It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration (PubMed:28807980). In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (PubMed:21193407). May regulate phagocytosis-induced apoptosis in extravasated neutrophils (By similarity). May play a role in mast cell development (By similarity). Required with TYROBP/DAP12 in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development (By similarity)