Mannose-binding protein C (MBP-C) (Collectin-1) (MBP1) (Mannan-binding protein) (Mannose-binding lectin)
1_MSLFP 6_ SLPLL 11_ LLSMV 16_ AASYS 21_ ETVTC 26_ EDAQK 31_ TCPAV 36_ IACSS 41_ PGING 46_ FPGKD 51_ GRDGT 56_ KGEKG 61_ EPGQG 66_ LRGLQ 71_ GPPGK 76_ LGPPG 81_ NPGPS 86_ GSPGP 91_ KGQKG 96_ DPGKS 101_ PDGDS 106_ SLAAS 111_ ERKAL 116_ QTEMA 121_ RIKKW 126_ LTFSL 131_ GKQVG 136_ NKFFL 141_ TNGEI 146_ MTFEK 151_ VKALC 156_ VKFQA 161_ SVATP 166_ RNAAE 171_ NGAIQ 176_ NLIKE 181_ EAFLG 186_ ITDEK 191_ TEGQF 196_ VDLTG 201_ NRLTY 206_ TNWNE 211_ GEPNN 216_ AGSDE 221_ DCVLL 226_ LKNGQ 231_ WNDVP 236_ CSTSH 241_LAVCE
1: Calcium-dependent lectin involved in innate immune defense (PubMed:35102342). Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA. Upon SARS coronavirus-2/SARS-CoV-2 infection, activates the complement lectin pathway which leads to the inhibition SARS-CoV-2 infection and a reduction of the induced inflammatory response (PubMed:35102342)