Ras-related protein Ral-A (EC 3.6.5.2)
1_MAANK 6_ PKGQN 11_ SLALH 16_ KVIMV 21_ GSGGV 26_ GKSAL 31_ TLQFM 36_ YDEFV 41_ EDYEP 46_ TKADS 51_ YRKKV 56_ VLDGE 61_ EVQID 66_ ILDTA 71_ GQEDY 76_ AAIRD 81_ NYFRS 86_ GEGFL 91_ CVFSI 96_ TEMES 101_ FAATA 106_ DFREQ 111_ ILRVK 116_ EDENV 121_ PFLLV 126_ GNKSD 131_ LEDKR 136_ QVSVE 141_ EAKNR 146_ AEQWN 151_ VNYVE 156_ TSAKT 161_ RANVD 166_ KVFFD 171_ LMREI 176_ RARKM 181_ EDSKE 186_ KNGKK 191_ KRKSL 196_ AKRIR 201_ERCCI
1: Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors (PubMed:18756269, PubMed:19306925, PubMed:20005108, PubMed:21822277, PubMed:30500825). Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. The RALA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling (PubMed:20005108). Key regulator of LPAR1 signaling and competes with GRK2 for binding to LPAR1 thus affecting the signaling properties of the receptor. Required for anchorage-independent proliferation of transformed cells (PubMed:19306925). During mitosis, supports the stabilization and elongation of the intracellular bridge between dividing cells. Cooperates with EXOC2 to recruit other components of the exocyst to the early midbody (PubMed:18756269). During mitosis, also controls mitochondrial fission by recruiting to the mitochondrion RALBP1, which mediates the phosphorylation and activation of DNM1L by the mitotic kinase cyclin B-CDK1 (PubMed:21822277)