Ras-related protein Ral-B (EC 3.6.5.2)
1_MAANK 6_ SKGQS 11_ SLALH 16_ KVIMV 21_ GSGGV 26_ GKSAL 31_ TLQFM 36_ YDEFV 41_ EDYEP 46_ TKADS 51_ YRKKV 56_ VLDGE 61_ EVQID 66_ ILDTA 71_ GQEDY 76_ AAIRD 81_ NYFRS 86_ GEGFL 91_ LVFSI 96_ TEHES 101_ FTATA 106_ EFREQ 111_ ILRVK 116_ AEEDK 121_ IPLLV 126_ VGNKS 131_ DLEER 136_ RQVPV 141_ EEARS 146_ KAEEW 151_ GVQYV 156_ ETSAK 161_ TRANV 166_ DKVFF 171_ DLMRE 176_ IRTKK 181_ MSENK 186_ DKNGK 191_ KSSKN 196_ KKSFK 201_ERCCL
1: Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking (PubMed:10393179, PubMed:17875936, PubMed:18756269). Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles (By similarity). Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells (By similarity). Required for suppression of apoptosis (PubMed:17875936). In late stages of cytokinesis, upon completion of the bridge formation between dividing cells, mediates exocyst recruitment to the midbody to drive abscission (PubMed:18756269). Involved in ligand-dependent receptor mediated endocytosis of the EGF and insulin receptors (PubMed:10393179)