Breakpoint cluster region protein (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-26)
1_MVDPV 6_ GFAEA 11_ WKAQF 16_ PDSEP 21_ PRMEL 26_ RSVGD 31_ IEQEL 36_ ERCKA 41_ SIRRL 46_ EQEVN 51_ QERFR 56_ MIYLQ 61_ TLLAK 66_ EKKSY 71_ DRQRW 76_ GFRRA 81_ AQAPD 86_ GASEP 91_ RASAS 96_ RPQPA 101_ PADGA 106_ DPPPA 111_ EEPEA 116_ RPDGE 121_ GSPGK 126_ ARPGT 131_ ARRPG 136_ AAASG 141_ ERDDR 146_ GPPAS 151_ VAALR 156_ SNFER 161_ IRKGH 166_ GQPGA 171_ DAEKP 176_ FYVNV 181_ EFHHE 186_ RGLVK 191_ VNDKE 196_ VSDRI 201_ SSLGS 206_ QAMQM 211_ ERKKS 216_ QHGAG 221_ SSVGD 226_ ASRPP 231_ YRGRS 236_ SESSC 241_ GVDGD 246_ YEDAE 251_ LNPRF 256_ LKDNL 261_ IDANG 266_ GSRPP 271_ WPPLE 276_ YQPYQ 281_ SIYVG 286_ GMMEG 291_ EGKGP 296_ LLRSQ 301_ STSEQ 306_ EKRLT 311_ WPRRS 316_ YSPRS 321_ FEDCG 326_ GGYTP 331_ DCSSN 336_ ENLTS 341_ SEEDF 346_ SSGQS 351_ SRVSP 356_ SPTTY 361_ RMFRD 366_ KSRSP 371_ SQNSQ 376_ QSFDS 381_ SSPPT 386_ PQCHK 391_ RHRHC 396_ PVVVS 401_ EATIV 406_ GVRKT 411_ GQIWP 416_ NDGEG 421_ AFHGD 426_ ADGSF 431_ GTPPG 436_ YGCAA 441_ DRAEE 446_ QRRHQ 451_ DGLPY 456_ IDDSP 461_ SSSPH 466_ LSSKG 471_ RGSRD 476_ ALVSG 481_ ALEST 486_ KASEL 491_ DLEKG 496_ LEMRK 501_ WVLSG 506_ ILASE 511_ ETYLS 516_ HLEAL 521_ LLPMK 526_ PLKAA 531_ ATTSQ 536_ PVLTS 541_ QQIET 546_ IFFKV 551_ PELYE 556_ IHKEF 561_ YDGLF 566_ PRVQQ 571_ WSHQQ 576_ RVGDL 581_ FQKLA 586_ SQLGV 591_ YRAFV 596_ DNYGV 601_ AMEMA 606_ EKCCQ 611_ ANAQF 616_ AEISE 621_ NLRAR 626_ SNKDA 631_ KDPTT 636_ KNSLE 641_ TLLYK 646_ PVDRV 651_ TRSTL 656_ VLHDL 661_ LKHTP 666_ ASHPD 671_ HPLLQ 676_ DALRI 681_ SQNFL 686_ SSINE 691_ EITPR 696_ RQSMT 701_ VKKGE 706_ HRQLL 711_ KDSFM 716_ VELVE 721_ GARKL 726_ RHVFL 731_ FTDLL 736_ LCTKL 741_ KKQSG 746_ GKTQQ 751_ YDCKW 756_ YIPLT 761_ DLSFQ 766_ MVDEL 771_ EAVPN 776_ IPLVP 781_ DEELD 786_ ALKIK 791_ ISQIK 796_ NDIQR 801_ EKRAN 806_ KGSKA 811_ TERLK 816_ KKLSE 821_ QESLL 826_ LLMSP 831_ SMAFR 836_ VHSRN 841_ GKSYT 846_ FLISS 851_ DYERA 856_ EWREN 861_ IREQQ 866_ KKCFR 871_ SFSLT 876_ SVELQ 881_ MLTNS 886_ CVKLQ 891_ TVHSI 896_ PLTIN 901_ KEDDE 906_ SPGLY 911_ GFLNV 916_ IVHSA 921_ TGFKQ 926_ SSNLY 931_ CTLEV 936_ DSFGY 941_ FVNKA 946_ KTRVY 951_ RDTAE 956_ PNWNE 961_ EFEIE 966_ LEGSQ 971_ TLRIL 976_ CYEKC 981_ YNKTK 986_ IPKED 991_ GESTD 996_ RLMGK 1001_ GQVQL 1006_ DPQAL 1011_ QDRDW 1016_ QRTVI 1021_ AMNGI 1026_ EVKLS 1031_ VKFNS 1036_ REFSL 1041_ KRMPS 1046_ RKQTG 1051_ VFGVK 1056_ IAVVT 1061_ KRERS 1066_ KVPYI 1071_ VRQCV 1076_ EEIER 1081_ RGMEE 1086_ VGIYR 1091_ VSGVA 1096_ TDIQA 1101_ LKAAF 1106_ DVNNK 1111_ DVSVM 1116_ MSEMD 1121_ VNAIA 1126_ GTLKL 1131_ YFREL 1136_ PEPLF 1141_ TDEFY 1146_ PNFAE 1151_ GIALS 1156_ DPVAK 1161_ ESCML 1166_ NLLLS 1171_ LPEAN 1176_ LLTFL 1181_ FLLDH 1186_ LKRVA 1191_ EKEAV 1196_ NKMSL 1201_ HNLAT 1206_ VFGPT 1211_ LLRPS 1216_ EKESK 1221_ LPANP 1226_ SQPIT 1231_ MTDSW 1236_ SLEVM 1241_ SQVQV 1246_ LLYFL 1251_ QLEAI 1256_ PAPDS 1261_ KRQSI 1266_LFSTE
1: Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein (GAP) domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form (PubMed:17116687, PubMed:1903516, PubMed:7479768). The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form (PubMed:23940119, PubMed:7479768). The amino terminus contains an intrinsic kinase activity (PubMed:1657398). Functions as an important negative regulator of neuronal RAC1 activity (By similarity). Regulates macrophage functions such as CSF1-directed motility and phagocytosis through the modulation of RAC1 activity (PubMed:17116687). Plays a major role as a RHOA GEF in keratinocytes being involved in focal adhesion formation and keratinocyte differentiation (PubMed:23940119)