Lysosome-associated membrane glycoprotein 1 (LAMP-1) (Lysosome-associated membrane protein 1) (CD107 antigen-like family member A) (CD antigen CD107a)
1_MAAPG 6_ SARRP 11_ LLLLL 16_ LLLLL 21_ GLMHC 26_ ASAAM 31_ FMVKN 36_ GNGTA 41_ CIMAN 46_ FSAAF 51_ SVNYD 56_ TKSGP 61_ KNMTF 66_ DLPSD 71_ ATVVL 76_ NRSSC 81_ GKENT 86_ SDPSL 91_ VIAFG 96_ RGHTL 101_ TLNFT 106_ RNATR 111_ YSVQL 116_ MSFVY 121_ NLSDT 126_ HLFPN 131_ ASSKE 136_ IKTVE 141_ SITDI 146_ RADID 151_ KKYRC 156_ VSGTQ 161_ VHMNN 166_ VTVTL 171_ HDATI 176_ QAYLS 181_ NSSFS 186_ RGETR 191_ CEQDR 196_ PSPTT 201_ APPAP 206_ PSPSP 211_ SPVPK 216_ SPSVD 221_ KYNVS 226_ GTNGT 231_ CLLAS 236_ MGLQL 241_ NLTYE 246_ RKDNT 251_ TVTRL 256_ LNINP 261_ NKTSA 266_ SGSCG 271_ AHLVT 276_ LELHS 281_ EGTTV 286_ LLFQF 291_ GMNAS 296_ SSRFF 301_ LQGIQ 306_ LNTIL 311_ PDARD 316_ PAFKA 321_ ANGSL 326_ RALQA 331_ TVGNS 336_ YKCNA 341_ EEHVR 346_ VTKAF 351_ SVNIF 356_ KVWVQ 361_ AFKVE 366_ GGQFG 371_ SVEEC 376_ LLDEN 381_ SMLIP 386_ IAVGG 391_ ALAGL 396_ VLIVL 401_ IAYLV 406_ GRKRS 411_HAGYQ
1: Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, lysosomal pH regulation, autophagy and cholesterol homeostasis (PubMed:37390818). Acts as an important regulator of lysosomal lumen pH regulation by acting as a direct inhibitor of the proton channel TMEM175, facilitating lysosomal acidification for optimal hydrolase activity (PubMed:37390818). Also plays an important role in NK-cells cytotoxicity (PubMed:2022921, PubMed:23632890). Mechanistically, participates in cytotoxic granule movement to the cell surface and perforin trafficking to the lytic granule (PubMed:23632890). In addition, protects NK-cells from degranulation-associated damage induced by their own cytotoxic granule content (PubMed:23847195). Presents carbohydrate ligands to selectins (PubMed:7685349)
2: (Microbial infection) Acts as a receptor for Lassa virus glycoprotein (PubMed:24970085, PubMed:25972533, PubMed:27605678, PubMed:28448640). Also promotes fusion of the virus with host membrane in less acidic endosomes (PubMed:29295909)
3: (Microbial infection) Supports the FURIN-mediated cleavage of mumps virus fusion protein F by interacting with both FURIN and the unprocessed form but not the processed form of the viral protein F