Medium-chain specific acyl-CoA dehydrogenase, mitochondrial (MCAD) (EC 1.3.8.7) (Medium chain acyl-CoA dehydrogenase) (MCADH)
1_MAAGF 6_ GRCCR 11_ VLRSI 16_ SRFHW 21_ RSQHT 26_ KANRQ 31_ REPGL 36_ GFSFE 41_ FTEQQ 46_ KEFQA 51_ TARKF 56_ AREEI 61_ IPVAA 66_ EYDKT 71_ GEYPV 76_ PLIRR 81_ AWELG 86_ LMNTH 91_ IPENC 96_ GGLGL 101_ GTFDA 106_ CLISE 111_ ELAYG 116_ CTGVQ 121_ TAIEG 126_ NSLGQ 131_ MPIII 136_ AGNDQ 141_ QKKKY 146_ LGRMT 151_ EEPLM 156_ CAYCV 161_ TEPGA 166_ GSDVA 171_ GIKTK 176_ AEKKG 181_ DEYII 186_ NGQKM 191_ WITNG 196_ GKANW 201_ YFLLA 206_ RSDPD 211_ PKAPA 216_ NKAFT 221_ GFIVE 226_ ADTPG 231_ IQIGR 236_ KELNM 241_ GQRCS 246_ DTRGI 251_ VFEDV 256_ KVPKE 261_ NVLIG 266_ DGAGF 271_ KVAMG 276_ AFDKT 281_ RPVVA 286_ AGAVG 291_ LAQRA 296_ LDEAT 301_ KYALE 306_ RKTFG 311_ KLLVE 316_ HQAIS 321_ FMLAE 326_ MAMKV 331_ ELARM 336_ SYQRA 341_ AWEVD 346_ SGRRN 351_ TYYAS 356_ IAKAF 361_ AGDIA 366_ NQLAT 371_ DAVQI 376_ LGGNG 381_ FNTEY 386_ PVEKL 391_ MRDAK 396_ IYQIY 401_ EGTSQ 406_ IQRLI 411_ VAREH 416_IDKYK
1: Medium-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats (PubMed:1970566, PubMed:21237683, PubMed:2251268, PubMed:8823175). The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA (PubMed:2251268). Electron transfer flavoprotein (ETF) is the electron acceptor that transfers electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (PubMed:15159392, PubMed:25416781). Among the different mitochondrial acyl-CoA dehydrogenases, medium-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 6 to 12 carbons long primary chains (PubMed:1970566, PubMed:21237683, PubMed:2251268, PubMed:8823175)