Fibroblast growth factor receptor 1 (FGFR-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (BFGFR) (bFGF-R-1) (Fms-like tyrosine kinase 2) (FLT-2) (N-sam) (Proto-oncogene c-Fgr) (CD antigen CD331)
1_MWSWK 6_ CLLFW 11_ AVLVT 16_ ATLCT 21_ ARPSP 26_ TLPEQ 31_ AQPWG 36_ APVEV 41_ ESFLV 46_ HPGDL 51_ LQLRC 56_ RLRDD 61_ VQSIN 66_ WLRDG 71_ VQLAE 76_ SNRTR 81_ ITGEE 86_ VEVQD 91_ SVPAD 96_ SGLYA 101_ CVTSS 106_ PSGSD 111_ TTYFS 116_ VNVSD 121_ ALPSS 126_ EDDDD 131_ DDDSS 136_ SEEKE 141_ TDNTK 146_ PNRMP 151_ VAPYW 156_ TSPEK 161_ MEKKL 166_ HAVPA 171_ AKTVK 176_ FKCPS 181_ SGTPN 186_ PTLRW 191_ LKNGK 196_ EFKPD 201_ HRIGG 206_ YKVRY 211_ ATWSI 216_ IMDSV 221_ VPSDK 226_ GNYTC 231_ IVENE 236_ YGSIN 241_ HTYQL 246_ DVVER 251_ SPHRP 256_ ILQAG 261_ LPANK 266_ TVALG 271_ SNVEF 276_ MCKVY 281_ SDPQP 286_ HIQWL 291_ KHIEV 296_ NGSKI 301_ GPDNL 306_ PYVQI 311_ LKTAG 316_ VNTTD 321_ KEMEV 326_ LHLRN 331_ VSFED 336_ AGEYT 341_ CLAGN 346_ SIGLS 351_ HHSAW 356_ LTVLE 361_ ALEER 366_ PAVMT 371_ SPLYL 376_ EIIIY 381_ CTGAF 386_ LISCM 391_ VGSVI 396_ VYKMK 401_ SGTKK 406_ SDFHS 411_ QMAVH 416_ KLAKS 421_ IPLRR 426_ QVTVS 431_ ADSSA 436_ SMNSG 441_ VLLVR 446_ PSRLS 451_ SSGTP 456_ MLAGV 461_ SEYEL 466_ PEDPR 471_ WELPR 476_ DRLVL 481_ GKPLG 486_ EGCFG 491_ QVVLA 496_ EAIGL 501_ DKDKP 506_ NRVTK 511_ VAVKM 516_ LKSDA 521_ TEKDL 526_ SDLIS 531_ EMEMM 536_ KMIGK 541_ HKNII 546_ NLLGA 551_ CTQDG 556_ PLYVI 561_ VEYAS 566_ KGNLR 571_ EYLQA 576_ RRPPG 581_ LEYCY 586_ NPSHN 591_ PEEQL 596_ SSKDL 601_ VSCAY 606_ QVARG 611_ MEYLA 616_ SKKCI 621_ HRDLA 626_ ARNVL 631_ VTEDN 636_ VMKIA 641_ DFGLA 646_ RDIHH 651_ IDYYK 656_ KTTNG 661_ RLPVK 666_ WMAPE 671_ ALFDR 676_ IYTHQ 681_ SDVWS 686_ FGVLL 691_ WEIFT 696_ LGGSP 701_ YPGVP 706_ VEELF 711_ KLLKE 716_ GHRMD 721_ KPSNC 726_ TNELY 731_ MMMRD 736_ CWHAV 741_ PSQRP 746_ TFKQL 751_ VEDLD 756_ RIVAL 761_ TSNQE 766_ YLDLS 771_ MPLDQ 776_ YSPSF 781_ PDTRS 786_ STCSS 791_ GEDSV 796_ FSHEP 801_ LPEEP 806_ CLPRH 811_ PAQLA 816_NGGLK
1: Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation