DNA topoisomerase 2-alpha (EC 5.6.2.2) (DNA topoisomerase II, alpha isozyme)
1_MEVSP 6_ LQPVN 11_ ENMQV 16_ NKIKK 21_ NEDAK 26_ KRLSV 31_ ERIYQ 36_ KKTQL 41_ EHILL 46_ RPDTY 51_ IGSVE 56_ LVTQQ 61_ MWVYD 66_ EDVGI 71_ NYREV 76_ TFVPG 81_ LYKIF 86_ DEILV 91_ NAADN 96_ KQRDP 101_ KMSCI 106_ RVTID 111_ PENNL 116_ ISIWN 121_ NGKGI 126_ PVVEH 131_ KVEKM 136_ YVPAL 141_ IFGQL 146_ LTSSN 151_ YDDDE 156_ KKVTG 161_ GRNGY 166_ GAKLC 171_ NIFST 176_ KFTVE 181_ TASRE 186_ YKKMF 191_ KQTWM 196_ DNMGR 201_ AGEME 206_ LKPFN 211_ GEDYT 216_ CITFQ 221_ PDLSK 226_ FKMQS 231_ LDKDI 236_ VALMV 241_ RRAYD 246_ IAGST 251_ KDVKV 256_ FLNGN 261_ KLPVK 266_ GFRSY 271_ VDMYL 276_ KDKLD 281_ ETGNS 286_ LKVIH 291_ EQVNH 296_ RWEVC 301_ LTMSE 306_ KGFQQ 311_ ISFVN 316_ SIATS 321_ KGGRH 326_ VDYVA 331_ DQIVT 336_ KLVDV 341_ VKKKN 346_ KGGVA 351_ VKAHQ 356_ VKNHM 361_ WIFVN 366_ ALIEN 371_ PTFDS 376_ QTKEN 381_ MTLQP 386_ KSFGS 391_ TCQLS 396_ EKFIK 401_ AAIGC 406_ GIVES 411_ ILNWV 416_ KFKAQ 421_ VQLNK 426_ KCSAV 431_ KHNRI 436_ KGIPK 441_ LDDAN 446_ DAGGR 451_ NSTEC 456_ TLILT 461_ EGDSA 466_ KTLAV 471_ SGLGV 476_ VGRDK 481_ YGVFP 486_ LRGKI 491_ LNVRE 496_ ASHKQ 501_ IMENA 506_ EINNI 511_ IKIVG 516_ LQYKK 521_ NYEDE 526_ DSLKT 531_ LRYGK 536_ IMIMT 541_ DQDQD 546_ GSHIK 551_ GLLIN 556_ FIHHN 561_ WPSLL 566_ RHRFL 571_ EEFIT 576_ PIVKV 581_ SKNKQ 586_ EMAFY 591_ SLPEF 596_ EEWKS 601_ STPNH 606_ KKWKV 611_ KYYKG 616_ LGTST 621_ SKEAK 626_ EYFAD 631_ MKRHR 636_ IQFKY 641_ SGPED 646_ DAAIS 651_ LAFSK 656_ KQIDD 661_ RKEWL 666_ TNFME 671_ DRRQR 676_ KLLGL 681_ PEDYL 686_ YGQTT 691_ TYLTY 696_ NDFIN 701_ KELIL 706_ FSNSD 711_ NERSI 716_ PSMVD 721_ GLKPG 726_ QRKVL 731_ FTCFK 736_ RNDKR 741_ EVKVA 746_ QLAGS 751_ VAEMS 756_ SYHHG 761_ EMSLM 766_ MTIIN 771_ LAQNF 776_ VGSNN 781_ LNLLQ 786_ PIGQF 791_ GTRLH 796_ GGKDS 801_ ASPRY 806_ IFTML 811_ SSLAR 816_ LLFPP 821_ KDDHT 826_ LKFLY 831_ DDNQR 836_ VEPEW 841_ YIPII 846_ PMVLI 851_ NGAEG 856_ IGTGW 861_ SCKIP 866_ NFDVR 871_ EIVNN 876_ IRRLM 881_ DGEEP 886_ LPMLP 891_ SYKNF 896_ KGTIE 901_ ELAPN 906_ QYVIS 911_ GEVAI 916_ LNSTT 921_ IEISE 926_ LPVRT 931_ WTQTY 936_ KEQVL 941_ EPMLN 946_ GTEKT 951_ PPLIT 956_ DYREY 961_ HTDTT 966_ VKFVV 971_ KMTEE 976_ KLAEA 981_ ERVGL 986_ HKVFK 991_ LQTSL 996_ TCNSM 1001_ VLFDH 1006_ VGCLK 1011_ KYDTV 1016_ LDILR 1021_ DFFEL 1026_ RLKYY 1031_ GLRKE 1036_ WLLGM 1041_ LGAES 1046_ AKLNN 1051_ QARFI 1056_ LEKID 1061_ GKIII 1066_ ENKPK 1071_ KELIK 1076_ VLIQR 1081_ GYDSD 1086_ PVKAW 1091_ KEAQQ 1096_ KVPDE 1101_ EENEE 1106_ SDNEK 1111_ ETEKS 1116_ DSVTD 1121_ SGPTF 1126_ NYLLD 1131_ MPLWY 1136_ LTKEK 1141_ KDELC 1146_ RLRNE 1151_ KEQEL 1156_ DTLKR 1161_ KSPSD 1166_ LWKED 1171_ LATFI 1176_ EELEA 1181_ VEAKE 1186_ KQDEQ 1191_ VGLPG 1196_ KGGKA 1201_ KGKKT 1206_ QMAEV 1211_ LPSPR 1216_ GQRVI 1221_ PRITI 1226_ EMKAE 1231_ AEKKN 1236_ KKKIK 1241_ NENTE 1246_ GSPQE 1251_ DGVEL 1256_ EGLKQ 1261_ RLEKK 1266_ QKREP 1271_ GTKTK 1276_ KQTTL 1281_ AFKPI 1286_ KKGKK 1291_ RNPWS 1296_ DSESD 1301_ RSSDE 1306_ SNFDV 1311_ PPRET 1316_ EPRRA 1321_ ATKTK 1326_ FTMDL 1331_ DSDED 1336_ FSDFD 1341_ EKTDD 1346_ EDFVP 1351_ SDASP 1356_ PKTKT 1361_ SPKLS 1366_ NKELK 1371_ PQKSV 1376_ VSDLE 1381_ ADDVK 1386_ GSVPL 1391_ SSSPP 1396_ ATHFP 1401_ DETEI 1406_ TNPVP 1411_ KKNVT 1416_ VKKTA 1421_ AKSQS 1426_ STSTT 1431_ GAKKR 1436_ AAPKG 1441_ TKRDP 1446_ ALNSG 1451_ VSQKP 1456_ DPAKT 1461_ KNRRK 1466_ RKPST 1471_ SDDSD 1476_ SNFEK 1481_ IVSKA 1486_ VTSKK 1491_ SKGES 1496_ DDFHM 1501_ DFDSA 1506_ VAPRA 1511_ KSVRA 1516_ KKPIK 1521_ YLEES 1526_DEDDL
1: Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand (PubMed:17567603, PubMed:18790802, PubMed:22013166, PubMed:22323612). May play a role in regulating the period length of BMAL1 transcriptional oscillation (By similarity)