Vitamin D3 receptor (VDR) (1,25-dihydroxyvitamin D3 receptor) (Nuclear receptor subfamily 1 group I member 1)
1_MEAMA 6_ ASTSL 11_ PDPGD 16_ FDRNV 21_ PRICG 26_ VCGDR 31_ ATGFH 36_ FNAMT 41_ CEGCK 46_ GFFRR 51_ SMKRK 56_ ALFTC 61_ PFNGD 66_ CRITK 71_ DNRRH 76_ CQACR 81_ LKRCV 86_ DIGMM 91_ KEFIL 96_ TDEEV 101_ QRKRE 106_ MILKR 111_ KEEEA 116_ LKDSL 121_ RPKLS 126_ EEQQR 131_ IIAIL 136_ LDAHH 141_ KTYDP 146_ TYSDF 151_ CQFRP 156_ PVRVN 161_ DGGGS 166_ HPSRP 171_ NSRHT 176_ PSFSG 181_ DSSSS 186_ CSDHC 191_ ITSSD 196_ MMDSS 201_ SFSNL 206_ DLSEE 211_ DSDDP 216_ SVTLE 221_ LSQLS 226_ MLPHL 231_ ADLVS 236_ YSIQK 241_ VIGFA 246_ KMIPG 251_ FRDLT 256_ SEDQI 261_ VLLKS 266_ SAIEV 271_ IMLRS 276_ NESFT 281_ MDDMS 286_ WTCGN 291_ QDYKY 296_ RVSDV 301_ TKAGH 306_ SLELI 311_ EPLIK 316_ FQVGL 321_ KKLNL 326_ HEEEH 331_ VLLMA 336_ ICIVS 341_ PDRPG 346_ VQDAA 351_ LIEAI 356_ QDRLS 361_ NTLQT 366_ YIRCR 371_ HPPPG 376_ SHLLY 381_ AKMIQ 386_ KLADL 391_ RSLNE 396_ EHSKQ 401_ YRCLS 406_ FQPEC 411_ SMKLT 416_ PLVLE 421_VFGNE
1: Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells (PubMed:10678179, PubMed:15728261, PubMed:16913708, PubMed:28698609, PubMed:37478846). Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR (PubMed:28698609). The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes (PubMed:28698609). Plays a central role in calcium homeostasis (By similarity). Also functions as a receptor for the secondary bile acid lithocholic acid (LCA) and its metabolites (PubMed:12016314, PubMed:32354638)