Steroid hormone receptor ERR1 (Estrogen receptor-like 1) (Estrogen-related receptor alpha) (ERR-alpha) (Nuclear receptor subfamily 3 group B member 1)
1_MSSQV 6_ VGIEP 11_ LYIKA 16_ EPASP 21_ DSPKG 26_ SSETE 31_ TEPPV 36_ ALAPG 41_ PAPTR 46_ CLPGH 51_ KEEED 56_ GEGAG 61_ PGEQG 66_ GGKLV 71_ LSSLP 76_ KRLCL 81_ VCGDV 86_ ASGYH 91_ YGVAS 96_ CEACK 101_ AFFKR 106_ TIQGS 111_ IEYSC 116_ PASNE 121_ CEITK 126_ RRRKA 131_ CQACR 136_ FTKCL 141_ RVGML 146_ KEGVR 151_ LDRVR 156_ GGRQK 161_ YKRRP 166_ EVDPL 171_ PFPGP 176_ FPAGP 181_ LAVAG 186_ GPRKT 191_ AAPVN 196_ ALVSH 201_ LLVVE 206_ PEKLY 211_ AMPDP 216_ AGPDG 221_ HLPAV 226_ ATLCD 231_ LFDRE 236_ IVVTI 241_ SWAKS 246_ IPGFS 251_ SLSLS 256_ DQMSV 261_ LQSVW 266_ MEVLV 271_ LGVAQ 276_ RSLPL 281_ QDELA 286_ FAEDL 291_ VLDEE 296_ GARAA 301_ GLGEL 306_ GAALL 311_ QLVRR 316_ LQALR 321_ LEREE 326_ YVLLK 331_ ALALA 336_ NSDSV 341_ HIEDA 346_ EAVEQ 351_ LREAL 356_ HEALL 361_ EYEAG 366_ RAGPG 371_ GGAER 376_ RRAGR 381_ LLLTL 386_ PLLRQ 391_ TAGKV 396_ LAHFY 401_ GVKLE 406_ GKVPM 411_ HKLFL 416_EMLEA
1: Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Induces the expression of PERM1 in the skeletal muscle