Guanine nucleotide-binding protein G(t) subunit alpha-1 (Transducin alpha-1 chain)
1_MGAGA 6_ SAEEK 11_ HSREL 16_ EKKLK 21_ EDAEK 26_ DARTV 31_ KLLLL 36_ GAGES 41_ GKSTI 46_ VKQMK 51_ IIHQD 56_ GYSLE 61_ ECLEF 66_ IAIIY 71_ GNTLQ 76_ SILAI 81_ VRAMT 86_ TLNIQ 91_ YGDSA 96_ RQDDA 101_ RKLMH 106_ MADTI 111_ EEGTM 116_ PKEMS 121_ DIIQR 126_ LWKDS 131_ GIQAC 136_ FERAS 141_ EYQLN 146_ DSAGY 151_ YLSDL 156_ ERLVT 161_ PGYVP 166_ TEQDV 171_ LRSRV 176_ KTTGI 181_ IETQF 186_ SFKDL 191_ NFRMF 196_ DVGGQ 201_ RSERK 206_ KWIHC 211_ FEGVT 216_ CIIFI 221_ AALSA 226_ YDMVL 231_ VEDDE 236_ VNRMH 241_ ESLHL 246_ FNSIC 251_ NHRYF 256_ ATTSI 261_ VLFLN 266_ KKDVF 271_ FEKIK 276_ KAHLS 281_ ICFPD 286_ YDGPN 291_ TYEDA 296_ GNYIK 301_ VQFLE 306_ LNMRR 311_ DVKEI 316_ YSHMT 321_ CATDT 326_ QNVKF 331_ VFDAV 336_ TDIII 341_KENLK
1: Functions as a signal transducer for the rod photoreceptor RHO. Required for normal RHO-mediated light perception by the retina (PubMed:22190596). Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs), such as the photoreceptor RHO. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Activated RHO promotes GDP release and GTP binding. Signaling is mediated via downstream effector proteins, such as cGMP-phosphodiesterase (By similarity)