Cytochrome P450 2A6 (EC 1.14.14.-) (1,4-cineole 2-exo-monooxygenase) (CYPIIA6) (Coumarin 7-hydroxylase) (Cytochrome P450 IIA3) (Cytochrome P450(I))
1_MLASG 6_ MLLVA 11_ LLVCL 16_ TVMVL 21_ MSVWQ 26_ QRKSK 31_ GKLPP 36_ GPTPL 41_ PFIGN 46_ YLQLN 51_ TEQMY 56_ NSLMK 61_ ISERY 66_ GPVFT 71_ IHLGP 76_ RRVVV 81_ LCGHD 86_ AVREA 91_ LVDQA 96_ EEFSG 101_ RGEQA 106_ TFDWV 111_ FKGYG 116_ VVFSN 121_ GERAK 126_ QLRRF 131_ SIATL 136_ RDFGV 141_ GKRGI 146_ EERIQ 151_ EEAGF 156_ LIDAL 161_ RGTGG 166_ ANIDP 171_ TFFLS 176_ RTVSN 181_ VISSI 186_ VFGDR 191_ FDYKD 196_ KEFLS 201_ LLRMM 206_ LGIFQ 211_ FTSTS 216_ TGQLY 221_ EMFSS 226_ VMKHL 231_ PGPQQ 236_ QAFQL 241_ LQGLE 246_ DFIAK 251_ KVEHN 256_ QRTLD 261_ PNSPR 266_ DFIDS 271_ FLIRM 276_ QEEEK 281_ NPNTE 286_ FYLKN 291_ LVMTT 296_ LNLFI 301_ GGTET 306_ VSTTL 311_ RYGFL 316_ LLMKH 321_ PEVEA 326_ KVHEE 331_ IDRVI 336_ GKNRQ 341_ PKFED 346_ RAKMP 351_ YMEAV 356_ IHEIQ 361_ RFGDV 366_ IPMSL 371_ ARRVK 376_ KDTKF 381_ RDFFL 386_ PKGTE 391_ VYPML 396_ GSVLR 401_ DPSFF 406_ SNPQD 411_ FNPQH 416_ FLNEK 421_ GQFKK 426_ SDAFV 431_ PFSIG 436_ KRNCF 441_ GEGLA 446_ RMELF 451_ LFFTT 456_ VMQNF 461_ RLKSS 466_ QSPKD 471_ IDVSP 476_ KHVGF 481_ ATIPR 486_NYTMS
1: Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of aflatoxin B1. Constitutes the major nicotine C-oxidase. Acts as a 1,4-cineole 2-exo-monooxygenase. Possesses low phenacetin O-deethylation activity