Aromatase (EC 1.14.14.14) (CYPXIX) (Cytochrome P-450AROM) (Cytochrome P450 19A1) (Estrogen synthase)
1_MVLEM 6_ LNPIH 11_ YNITS 16_ IVPEA 21_ MPAAT 26_ MPVLL 31_ LTGLF 36_ LLVWN 41_ YEGTS 46_ SIPGP 51_ GYCMG 56_ IGPLI 61_ SHGRF 66_ LWMGI 71_ GSACN 76_ YYNRV 81_ YGEFM 86_ RVWIS 91_ GEETL 96_ IISKS 101_ SSMFH 106_ IMKHN 111_ HYSSR 116_ FGSKL 121_ GLQCI 126_ GMHEK 131_ GIIFN 136_ NNPEL 141_ WKTTR 146_ PFFMK 151_ ALSGP 156_ GLVRM 161_ VTVCA 166_ ESLKT 171_ HLDRL 176_ EEVTN 181_ ESGYV 186_ DVLTL 191_ LRRVM 196_ LDTSN 201_ TLFLR 206_ IPLDE 211_ SAIVV 216_ KIQGY 221_ FDAWQ 226_ ALLIK 231_ PDIFF 236_ KISWL 241_ YKKYE 246_ KSVKD 251_ LKDAI 256_ EVLIA 261_ EKRRR 266_ ISTEE 271_ KLEEC 276_ MDFAT 281_ ELILA 286_ EKRGD 291_ LTREN 296_ VNQCI 301_ LEMLI 306_ AAPDT 311_ MSVSL 316_ FFMLF 321_ LIAKH 326_ PNVEE 331_ AIIKE 336_ IQTVI 341_ GERDI 346_ KIDDI 351_ QKLKV 356_ MENFI 361_ YESMR 366_ YQPVV 371_ DLVMR 376_ KALED 381_ DVIDG 386_ YPVKK 391_ GTNII 396_ LNIGR 401_ MHRLE 406_ FFPKP 411_ NEFTL 416_ ENFAK 421_ NVPYR 426_ YFQPF 431_ GFGPR 436_ GCAGK 441_ YIAMV 446_ MMKAI 451_ LVTLL 456_ RRFHV 461_ KTLQG 466_ QCVES 471_ IQKIH 476_ DLSLH 481_ PDETK 486_ NMLEM 491_ IFTPR 496_NSDRC
1: A cytochrome P450 monooxygenase that catalyzes the conversion of C19 androgens, androst-4-ene-3,17-dione (androstenedione) and testosterone to the C18 estrogens, estrone and estradiol, respectively (PubMed:27702664, PubMed:2848247). Catalyzes three successive oxidations of C19 androgens: two conventional oxidations at C19 yielding 19-hydroxy and 19-oxo/19-aldehyde derivatives, followed by a third oxidative aromatization step that involves C1-beta hydrogen abstraction combined with cleavage of the C10-C19 bond to yield a phenolic A ring and formic acid (PubMed:20385561). Alternatively, the third oxidative reaction yields a 19-norsteroid and formic acid. Converts dihydrotestosterone to delta1,10-dehydro 19-nordihydrotestosterone and may play a role in homeostasis of this potent androgen (PubMed:22773874). Also displays 2-hydroxylase activity toward estrone (PubMed:22773874). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:20385561, PubMed:22773874)