C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) (Epididymis secretory sperm binding protein) [Cleaved into: C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed] [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate synthetase (EC 6.3.4.3)]
1_MAPAE 6_ ILNGK 11_ EISAQ 16_ IRARL 21_ KNQVT 26_ QLKEQ 31_ VPGFT 36_ PRLAI 41_ LQVGN 46_ RDDSN 51_ LYINV 56_ KLKAA 61_ EEIGI 66_ KATHI 71_ KLPRT 76_ TTESE 81_ VMKYI 86_ TSLNE 91_ DSTVH 96_ GFLVQ 101_ LPLDS 106_ ENSIN 111_ TEEVI 116_ NAIAP 121_ EKDVD 126_ GLTSI 131_ NAGKL 136_ ARGDL 141_ NDCFI 146_ PCTPK 151_ GCLEL 156_ IKETG 161_ VPIAG 166_ RHAVV 171_ VGRSK 176_ IVGAP 181_ MHDLL 186_ LWNNA 191_ TVTTC 196_ HSKTA 201_ HLDEE 206_ VNKGD 211_ ILVVA 216_ TGQPE 221_ MVKGE 226_ WIKPG 231_ AIVID 236_ CGINY 241_ VPDDK 246_ KPNGR 251_ KVVGD 256_ VAYDE 261_ AKERA 266_ SFITP 271_ VPGGV 276_ GPMTV 281_ AMLMQ 286_ STVES 291_ AKRFL 296_ EKFKP 301_ GKWMI 306_ QYNNL 311_ NLKTP 316_ VPSDI 321_ DISRS 326_ CKPKP 331_ IGKLA 336_ REIGL 341_ LSEEV 346_ ELYGE 351_ TKAKV 356_ LLSAL 361_ ERLKH 366_ RPDGK 371_ YVVVT 376_ GITPT 381_ PLGEG 386_ KSTTT 391_ IGLVQ 396_ ALGAH 401_ LYQNV 406_ FACVR 411_ QPSQG 416_ PTFGI 421_ KGGAA 426_ GGGYS 431_ QVIPM 436_ EEFNL 441_ HLTGD 446_ IHAIT 451_ AANNL 456_ VAAAI 461_ DARIF 466_ HELTQ 471_ TDKAL 476_ FNRLV 481_ PSVNG 486_ VRRFS 491_ DIQIR 496_ RLKRL 501_ GIEKT 506_ DPTTL 511_ TDEEI 516_ NRFAR 521_ LDIDP 526_ ETITW 531_ QRVLD 536_ TNDRF 541_ LRKIT 546_ IGQAP 551_ TEKGH 556_ TRTAQ 561_ FDISV 566_ ASEIM 571_ AVLAL 576_ TTSLE 581_ DMRER 586_ LGKMV 591_ VASSK 596_ KGEPV 601_ SAEDL 606_ GVSGA 611_ LTVLM 616_ KDAIK 621_ PNLMQ 626_ TLEGT 631_ PVFVH 636_ AGPFA 641_ NIAHG 646_ NSSII 651_ ADRIA 656_ LKLVG 661_ PEGFV 666_ VTEAG 671_ FGADI 676_ GMEKF 681_ FNIKC 686_ RYSGL 691_ CPHVV 696_ VLVAT 701_ VRALK 706_ MHGGG 711_ PTVTA 716_ GLPLP 721_ KAYIQ 726_ ENLEL 731_ VEKGF 736_ SNLKK 741_ QIENA 746_ RMFGI 751_ PVVVA 756_ VNAFK 761_ TDTES 766_ ELDLI 771_ SRLSR 776_ EHGAF 781_ DAVKC 786_ THWAE 791_ GGKGA 796_ LALAQ 801_ AVQRA 806_ AQAPS 811_ SFQLL 816_ YDLKL 821_ PVEDK 826_ IRIIA 831_ QKIYG 836_ ADDIE 841_ LLPEA 846_ QHKAE 851_ VYTKQ 856_ GFGNL 861_ PICMA 866_ KTHLS 871_ LSHNP 876_ EQKGV 881_ PTGFI 886_ LPIRD 891_ IRASV 896_ GAGFL 901_ YPLVG 906_ TMSTM 911_ PGLPT 916_ RPCFY 921_ DIDLD 926_PETEQ
1: Trifunctional enzyme that catalyzes the interconversion of three forms of one-carbon-substituted tetrahydrofolate: (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate, 5,10-methenyltetrahydrofolate and (6S)-10-formyltetrahydrofolate (PubMed:10828945, PubMed:18767138, PubMed:1881876). These derivatives of tetrahydrofolate are differentially required in nucleotide and amino acid biosynthesis, (6S)-10-formyltetrahydrofolate being required for purine biosynthesis while (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate is used for serine and methionine biosynthesis for instance (PubMed:18767138, PubMed:25633902)