Cytochrome P450 2C9 (EC 1.14.14.1) ((R)-limonene 6-monooxygenase) (EC 1.14.14.53) ((S)-limonene 6-monooxygenase) (EC 1.14.14.51) ((S)-limonene 7-monooxygenase) (EC 1.14.14.52) (CYPIIC9) (Cholesterol 25-hydroxylase) (Cytochrome P-450MP) (Cytochrome P450 MP-4) (Cytochrome P450 MP-8) (Cytochrome P450 PB-1) (S-mephenytoin 4-hydroxylase)
1_MDSLV 6_ VLVLC 11_ LSCLL 16_ LLSLW 21_ RQSSG 26_ RGKLP 31_ PGPTP 36_ LPVIG 41_ NILQI 46_ GIKDI 51_ SKSLT 56_ NLSKV 61_ YGPVF 66_ TLYFG 71_ LKPIV 76_ VLHGY 81_ EAVKE 86_ ALIDL 91_ GEEFS 96_ GRGIF 101_ PLAER 106_ ANRGF 111_ GIVFS 116_ NGKKW 121_ KEIRR 126_ FSLMT 131_ LRNFG 136_ MGKRS 141_ IEDRV 146_ QEEAR 151_ CLVEE 156_ LRKTK 161_ ASPCD 166_ PTFIL 171_ GCAPC 176_ NVICS 181_ IIFHK 186_ RFDYK 191_ DQQFL 196_ NLMEK 201_ LNENI 206_ KILSS 211_ PWIQI 216_ CNNFS 221_ PIIDY 226_ FPGTH 231_ NKLLK 236_ NVAFM 241_ KSYIL 246_ EKVKE 251_ HQESM 256_ DMNNP 261_ QDFID 266_ CFLMK 271_ MEKEK 276_ HNQPS 281_ EFTIE 286_ SLENT 291_ AVDLF 296_ GAGTE 301_ TTSTT 306_ LRYAL 311_ LLLLK 316_ HPEVT 321_ AKVQE 326_ EIERV 331_ IGRNR 336_ SPCMQ 341_ DRSHM 346_ PYTDA 351_ VVHEV 356_ QRYID 361_ LLPTS 366_ LPHAV 371_ TCDIK 376_ FRNYL 381_ IPKGT 386_ TILIS 391_ LTSVL 396_ HDNKE 401_ FPNPE 406_ MFDPH 411_ HFLDE 416_ GGNFK 421_ KSKYF 426_ MPFSA 431_ GKRIC 436_ VGEAL 441_ AGMEL 446_ FLFLT 451_ SILQN 456_ FNLKS 461_ LVDPK 466_ NLDTT 471_ PVVNG 476_ FASVP 481_PFYQL
1: A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids and steroids (PubMed:12865317, PubMed:15766564, PubMed:19965576, PubMed:21576599, PubMed:7574697, PubMed:9435160, PubMed:9866708). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:12865317, PubMed:15766564, PubMed:19965576, PubMed:21576599, PubMed:7574697, PubMed:9435160, PubMed:9866708). Catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFA) (PubMed:15766564, PubMed:19965576, PubMed:7574697, PubMed:9866708). Catalyzes the hydroxylation of carbon-hydrogen bonds. Metabolizes cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis (PubMed:21576599). Exhibits low catalytic activity for the formation of catechol estrogens from 17beta-estradiol (E2) and estrone (E1), namely 2-hydroxy E1 and E2 (PubMed:12865317). Catalyzes bisallylic hydroxylation and hydroxylation with double-bond migration of polyunsaturated fatty acids (PUFA) (PubMed:9435160, PubMed:9866708). Also metabolizes plant monoterpenes such as limonene. Oxygenates (R)- and (S)-limonene to produce carveol and perillyl alcohol (PubMed:11950794). Contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan (PubMed:25994031)