Cation-independent mannose-6-phosphate receptor (CI Man-6-P receptor) (CI-MPR) (M6PR) (300 kDa mannose 6-phosphate receptor) (MPR 300) (Insulin-like growth factor 2 receptor) (Insulin-like growth factor II receptor) (IGF-II receptor) (M6P/IGF2 receptor) (M6P/IGF2R) (CD antigen CD222)
1_MGAAA 6_ GRSPH 11_ LGPAP 16_ ARRPQ 21_ RSLLL 26_ LQLLL 31_ LVAAP 36_ GSTQA 41_ QAAPF 46_ PELCS 51_ YTWEA 56_ VDTKN 61_ NVLYK 66_ INICG 71_ SVDIV 76_ QCGPS 81_ SAVCM 86_ HDLKT 91_ RTYHS 96_ VGDSV 101_ LRSAT 106_ RSLLE 111_ FNTTV 116_ SCDQQ 121_ GTNHR 126_ VQSSI 131_ AFLCG 136_ KTLGT 141_ PEFVT 146_ ATECV 151_ HYFEW 156_ RTTAA 161_ CKKDI 166_ FKANK 171_ EVPCY 176_ VFDEE 181_ LRKHD 186_ LNPLI 191_ KLSGA 196_ YLVDD 201_ SDPDT 206_ SLFIN 211_ VCRDI 216_ DTLRD 221_ PGSQL 226_ RACPP 231_ GTAAC 236_ LVRGH 241_ QAFDV 246_ GQPRD 251_ GLKLV 256_ RKDRL 261_ VLSYV 266_ REEAG 271_ KLDFC 276_ DGHSP 281_ AVTIT 286_ FVCPS 291_ ERREG 296_ TIPKL 301_ TAKSN 306_ CRYEI 311_ EWITE 316_ YACHR 321_ DYLES 326_ KTCSL 331_ SGEQQ 336_ DVSID 341_ LTPLA 346_ QSGGS 351_ SYISD 356_ GKEYL 361_ FYLNV 366_ CGETE 371_ IQFCN 376_ KKQAA 381_ VCQVK 386_ KSDTS 391_ QVKAA 396_ GRYHN 401_ QTLRY 406_ SDGDL 411_ TLIYF 416_ GGDEC 421_ SSGFQ 426_ RMSVI 431_ NFECN 436_ KTAGN 441_ DGKGT 446_ PVFTG 451_ EVDCT 456_ YFFTW 461_ DTEYA 466_ CVKEK 471_ EDLLC 476_ GATDG 481_ KKRYD 486_ LSALV 491_ RHAEP 496_ EQNWE 501_ AVDGS 506_ QTETE 511_ KKHFF 516_ INICH 521_ RVLQE 526_ GKARG 531_ CPEDA 536_ AVCAV 541_ DKNGS 546_ KNLGK 551_ FISSP 556_ MKEKG 561_ NIQLS 566_ YSDGD 571_ DCGHG 576_ KKIKT 581_ NITLV 586_ CKPGD 591_ LESAP 596_ VLRTS 601_ GEGGC 606_ FYEFE 611_ WHTAA 616_ ACVLS 621_ KTEGE 626_ NCTVF 631_ DSQAG 636_ FSFDL 641_ SPLTK 646_ KNGAY 651_ KVETK 656_ KYDFY 661_ INVCG 666_ PVSVS 671_ PCQPD 676_ SGACQ 681_ VAKSD 686_ EKTWN 691_ LGLSN 696_ AKLSY 701_ YDGMI 706_ QLNYR 711_ GGTPY 716_ NNERH 721_ TPRAT 726_ LITFL 731_ CDRDA 736_ GVGFP 741_ EYQEE 746_ DNSTY 751_ NFRWY 756_ TSYAC 761_ PEEPL 766_ ECVVT 771_ DPSTL 776_ EQYDL 781_ SSLAK 786_ SEGGL 791_ GGNWY 796_ AMDNS 801_ GEHVT 806_ WRKYY 811_ INVCR 816_ PLNPV 821_ PGCNR 826_ YASAC 831_ QMKYE 836_ KDQGS 841_ FTEVV 846_ SISNL 851_ GMAKT 856_ GPVVE 861_ DSGSL 866_ LLEYV 871_ NGSAC 876_ TTSDG 881_ RQTTY 886_ TTRIH 891_ LVCSR 896_ GRLNS 901_ HPIFS 906_ LNWEC 911_ VVSFL 916_ WNTEA 921_ ACPIQ 926_ TTTDT 931_ DQACS 936_ IRDPN 941_ SGFVF 946_ NLNPL 951_ NSSQG 956_ YNVSG 961_ IGKIF 966_ MFNVC 971_ GTMPV 976_ CGTIL 981_ GKPAS 986_ GCEAE 991_ TQTEE 996_ LKNWK 1001_ PARPV 1006_ GIEKS 1011_ LQLST 1016_ EGFIT 1021_ LTYKG 1026_ PLSAK 1031_ GTADA 1036_ FIVRF 1041_ VCNDD 1046_ VYSGP 1051_ LKFLH 1056_ QDIDS 1061_ GQGIR 1066_ NTYFE 1071_ FETAL 1076_ ACVPS 1081_ PVDCQ 1086_ VTDLA 1091_ GNEYD 1096_ LTGLS 1101_ TVRKP 1106_ WTAVD 1111_ TSVDG 1116_ RKRTF 1121_ YLSVC 1126_ NPLPY 1131_ IPGCQ 1136_ GSAVG 1141_ SCLVS 1146_ EGNSW 1151_ NLGVV 1156_ QMSPQ 1161_ AAANG 1166_ SLSIM 1171_ YVNGD 1176_ KCGNQ 1181_ RFSTR 1186_ ITFEC 1191_ AQISG 1196_ SPAFQ 1201_ LQDGC 1206_ EYVFI 1211_ WRTVE 1216_ ACPVV 1221_ RVEGD 1226_ NCEVK 1231_ DPRHG 1236_ NLYDL 1241_ KPLGL 1246_ NDTIV 1251_ SAGEY 1256_ TYYFR 1261_ VCGKL 1266_ SSDVC 1271_ PTSDK 1276_ SKVVS 1281_ SCQEK 1286_ REPQG 1291_ FHKVA 1296_ GLLTQ 1301_ KLTYE 1306_ NGLLK 1311_ MNFTG 1316_ GDTCH 1321_ KVYQR 1326_ STAIF 1331_ FYCDR 1336_ GTQRP 1341_ VFLKE 1346_ TSDCS 1351_ YLFEW 1356_ RTQYA 1361_ CPPFD 1366_ LTECS 1371_ FKDGA 1376_ GNSFD 1381_ LSSLS 1386_ RYSDN 1391_ WEAIT 1396_ GTGDP 1401_ EHYLI 1406_ NVCKS 1411_ LAPQA 1416_ GTEPC 1421_ PPEAA 1426_ ACLLG 1431_ GSKPV 1436_ NLGRV 1441_ RDGPQ 1446_ WRDGI 1451_ IVLKY 1456_ VDGDL 1461_ CPDGI 1466_ RKKST 1471_ TIRFT 1476_ CSESQ 1481_ VNSRP 1486_ MFISA 1491_ VEDCE 1496_ YTFAW 1501_ PTATA 1506_ CPMKS 1511_ NEHDD 1516_ CQVTN 1521_ PSTGH 1526_ LFDLS 1531_ SLSGR 1536_ AGFTA 1541_ AYSEK 1546_ GLVYM 1551_ SICGE 1556_ NENCP 1561_ PGVGA 1566_ CFGQT 1571_ RISVG 1576_ KANKR 1581_ LRYVD 1586_ QVLQL 1591_ VYKDG 1596_ SPCPS 1601_ KSGLS 1606_ YKSVI 1611_ SFVCR 1616_ PEARP 1621_ TNRPM 1626_ LISLD 1631_ KQTCT 1636_ LFFSW 1641_ HTPLA 1646_ CEQAT 1651_ ECSVR 1656_ NGSSI 1661_ VDLSP 1666_ LIHRT 1671_ GGYEA 1676_ YDESE 1681_ DDASD 1686_ TNPDF 1691_ YINIC 1696_ QPLNP 1701_ MHGVP 1706_ CPAGA 1711_ AVCKV 1716_ PIDGP 1721_ PIDIG 1726_ RVAGP 1731_ PILNP 1736_ IANEI 1741_ YLNFE 1746_ SSTPC 1751_ LADKH 1756_ FNYTS 1761_ LIAFH 1766_ CKRGV 1771_ SMGTP 1776_ KLLRT 1781_ SECDF 1786_ VFEWE 1791_ TPVVC 1796_ PDEVR 1801_ MDGCT 1806_ LTDEQ 1811_ LLYSF 1816_ NLSSL 1821_ STSTF 1826_ KVTRD 1831_ SRTYS 1836_ VGVCT 1841_ FAVGP 1846_ EQGGC 1851_ KDGGV 1856_ CLLSG 1861_ TKGAS 1866_ FGRLQ 1871_ SMKLD 1876_ YRHQD 1881_ EAVVL 1886_ SYVNG 1891_ DRCPP 1896_ ETDDG 1901_ VPCVF 1906_ PFIFN 1911_ GKSYE 1916_ ECIIE 1921_ SRAKL 1926_ WCSTT 1931_ ADYDR 1936_ DHEWG 1941_ FCRHS 1946_ NSYRT 1951_ SSIIF 1956_ KCDED 1961_ EDIGR 1966_ PQVFS 1971_ EVRGC 1976_ DVTFE 1981_ WKTKV 1986_ VCPPK 1991_ KLECK 1996_ FVQKH 2001_ KTYDL 2006_ RLLSS 2011_ LTGSW 2016_ SLVHN 2021_ GVSYY 2026_ INLCQ 2031_ KIYKG 2036_ PLGCS 2041_ ERASI 2046_ CRRTT 2051_ TGDVQ 2056_ VLGLV 2061_ HTQKL 2066_ GVIGD 2071_ KVVVT 2076_ YSKGY 2081_ PCGGN 2086_ KTASS 2091_ VIELT 2096_ CTKTV 2101_ GRPAF 2106_ KRFDI 2111_ DSCTY 2116_ YFSWD 2121_ SRAAC 2126_ AVKPQ 2131_ EVQMV 2136_ NGTIT 2141_ NPING 2146_ KSFSL 2151_ GDIYF 2156_ KLFRA 2161_ SGDMR 2166_ TNGDN 2171_ YLYEI 2176_ QLSSI 2181_ TSSRN 2186_ PACSG 2191_ ANICQ 2196_ VKPND 2201_ QHFSR 2206_ KVGTS 2211_ DKTKY 2216_ YLQDG 2221_ DLDVV 2226_ FASSS 2231_ KCGKD 2236_ KTKSV 2241_ SSTIF 2246_ FHCDP 2251_ LVEDG 2256_ IPEFS 2261_ HETAD 2266_ CQYLF 2271_ SWYTS 2276_ AVCPL 2281_ GVGFD 2286_ SENPG 2291_ DDGQM 2296_ HKGLS 2301_ ERSQA 2306_ VGAVL 2311_ SLLLV 2316_ ALTCC 2321_ LLALL 2326_ LYKKE 2331_ RRETV 2336_ ISKLT 2341_ TCCRR 2346_ SSNVS 2351_ YKYSK 2356_ VNKEE 2361_ ETDEN 2366_ ETEWL 2371_ MEEIQ 2376_ LPPPR 2381_ QGKEG 2386_ QENGH 2391_ ITTKS 2396_ VKALS 2401_ SLHGD 2406_ DQDSE 2411_ DEVLT 2416_ IPEVK 2421_ VHSGR 2426_ GAGAE 2431_ SSHPV 2436_ RNAQS 2441_ NALQE 2446_ REDDR 2451_ VGLVR 2456_ GEKAR 2461_ KGKSS 2466_ SAQQK 2471_ TVSST 2476_ KLVSF 2481_ HDDSD 2486_EDLLH
1: Mediates the transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes (PubMed:18817523, PubMed:2963003). Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex (PubMed:18817523, PubMed:2963003). The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer (PubMed:18817523). This receptor also binds IGF2 (PubMed:18046459). Acts as a positive regulator of T-cell coactivation by binding DPP4 (PubMed:10900005)