Alcohol dehydrogenase class-3 (EC 1.1.1.1) (Alcohol dehydrogenase 5) (Alcohol dehydrogenase class chi chain) (Alcohol dehydrogenase class-III) (Glutathione-dependent formaldehyde dehydrogenase) (FALDH) (FDH) (GSH-FDH) (EC 1.1.1.-) (S-(hydroxymethyl)glutathione dehydrogenase) (EC 1.1.1.284)
1_MANEV 6_ IKCKA 11_ AVAWE 16_ AGKPL 21_ SIEEI 26_ EVAPP 31_ KAHEV 36_ RIKII 41_ ATAVC 46_ HTDAY 51_ TLSGA 56_ DPEGC 61_ FPVIL 66_ GHEGA 71_ GIVES 76_ VGEGV 81_ TKLKA 86_ GDTVI 91_ PLYIP 96_ QCGEC 101_ KFCLN 106_ PKTNL 111_ CQKIR 116_ VTQGK 121_ GLMPD 126_ GTSRF 131_ TCKGK 136_ TILHY 141_ MGTST 146_ FSEYT 151_ VVADI 156_ SVAKI 161_ DPLAP 166_ LDKVC 171_ LLGCG 176_ ISTGY 181_ GAAVN 186_ TAKLE 191_ PGSVC 196_ AVFGL 201_ GGVGL 206_ AVIMG 211_ CKVAG 216_ ASRII 221_ GVDIN 226_ KDKFA 231_ RAKEF 236_ GATEC 241_ INPQD 246_ FSKPI 251_ QEVLI 256_ EMTDG 261_ GVDYS 266_ FECIG 271_ NVKVM 276_ RAALE 281_ ACHKG 286_ WGVSV 291_ VVGVA 296_ ASGEE 301_ IATRP 306_ FQLVT 311_ GRTWK 316_ GTAFG 321_ GWKSV 326_ ESVPK 331_ LVSEY 336_ MSKKI 341_ KVDEF 346_ VTHNL 351_ SFDEI 356_ NKAFE 361_ LMHSG 366_KSIRT
1: Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione (PubMed:8460164). Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate (PubMed:16081420). Class-III ADH is remarkably ineffective in oxidizing ethanol (PubMed:8460164). Required for clearance of cellular formaldehyde, a cytotoxic and carcinogenic metabolite that induces DNA damage (PubMed:33355142). Also acts as a S-nitroso-glutathione reductase by catalyzing the NADH-dependent reduction of S-nitrosoglutathione, thereby regulating protein S-nitrosylation (By similarity)