Serum response factor (SRF)
1_MLPTQ 6_ AGAAA 11_ ALGRG 16_ SALGG 21_ SLNRT 26_ PTGRP 31_ GGGGG 36_ TRGAN 41_ GGRVP 46_ GNGAG 51_ LGPGR 56_ LEREA 61_ AAAAA 66_ TTPAP 71_ TAGAL 76_ YSGSE 81_ GDSES 86_ GEEEE 91_ LGAER 96_ RGLKR 101_ SLSEM 106_ EIGMV 111_ VGGPE 116_ ASAAA 121_ TGGYG 126_ PVSGA 131_ VSGAK 136_ PGKKT 141_ RGRVK 146_ IKMEF 151_ IDNKL 156_ RRYTT 161_ FSKRK 166_ TGIMK 171_ KAYEL 176_ STLTG 181_ TQVLL 186_ LVASE 191_ TGHVY 196_ TFATR 201_ KLQPM 206_ ITSET 211_ GKALI 216_ QTCLN 221_ SPDSP 226_ PRSDP 231_ TTDQR 236_ MSATG 241_ FEETD 246_ LTYQV 251_ SESDS 256_ SGETK 261_ DTLKP 266_ AFTVT 271_ NLPGT 276_ TSTIQ 281_ TAPST 286_ STTMQ 291_ VSSGP 296_ SFPIT 301_ NYLAP 306_ VSASV 311_ SPSAV 316_ SSANG 321_ TVLKS 326_ TGSGP 331_ VSSGG 336_ LMQLP 341_ TSFTL 346_ MPGGA 351_ VAQQV 356_ PVQAI 361_ QVHQA 366_ PQQAS 371_ PSRDS 376_ STDLT 381_ QTSSS 386_ GTVTL 391_ PATIM 396_ TSSVP 401_ TTVGG 406_ HMMYP 411_ SPHAV 416_ MYAPT 421_ SGLGD 426_ GSLTV 431_ LNAFS 436_ QAPST 441_ MQVSH 446_ SQVQE 451_ PGGVP 456_ QVFLT 461_ ASSGT 466_ VQIPV 471_ SAVQL 476_ HQMAV 481_ IGQQA 486_ GSSSN 491_ LTELQ 496_ VVNLD 501_TAHST
1: SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Together with MRTFA transcription coactivator, controls expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration. The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. Required for cardiac differentiation and maturation