Polyadenylate-binding protein 1 (PABP-1) (Poly(A)-binding protein 1)
1_MNPSA 6_ PSYPM 11_ ASLYV 16_ GDLHP 21_ DVTEA 26_ MLYEK 31_ FSPAG 36_ PILSI 41_ RVCRD 46_ MITRR 51_ SLGYA 56_ YVNFQ 61_ QPADA 66_ ERALD 71_ TMNFD 76_ VIKGK 81_ PVRIM 86_ WSQRD 91_ PSLRK 96_ SGVGN 101_ IFIKN 106_ LDKSI 111_ DNKAL 116_ YDTFS 121_ AFGNI 126_ LSCKV 131_ VCDEN 136_ GSKGY 141_ GFVHF 146_ ETQEA 151_ AERAI 156_ EKMNG 161_ MLLND 166_ RKVFV 171_ GRFKS 176_ RKERE 181_ AELGA 186_ RAKEF 191_ TNVYI 196_ KNFGE 201_ DMDDE 206_ RLKDL 211_ FGKFG 216_ PALSV 221_ KVMTD 226_ ESGKS 231_ KGFGF 236_ VSFER 241_ HEDAQ 246_ KAVDE 251_ MNGKE 256_ LNGKQ 261_ IYVGR 266_ AQKKV 271_ ERQTE 276_ LKRKF 281_ EQMKQ 286_ DRITR 291_ YQGVN 296_ LYVKN 301_ LDDGI 306_ DDERL 311_ RKEFS 316_ PFGTI 321_ TSAKV 326_ MMEGG 331_ RSKGF 336_ GFVCF 341_ SSPEE 346_ ATKAV 351_ TEMNG 356_ RIVAT 361_ KPLYV 366_ ALAQR 371_ KEERQ 376_ AHLTN 381_ QYMQR 386_ MASVR 391_ AVPNP 396_ VINPY 401_ QPAPP 406_ SGYFM 411_ AAIPQ 416_ TQNRA 421_ AYYPP 426_ SQIAQ 431_ LRPSP 436_ RWTAQ 441_ GARPH 446_ PFQNM 451_ PGAIR 456_ PAAPR 461_ PPFST 466_ MRPAS 471_ SQVPR 476_ VMSTQ 481_ RVANT 486_ STQTM 491_ GPRPA 496_ AAAAA 501_ ATPAV 506_ RTVPQ 511_ YKYAA 516_ GVRNP 521_ QQHLN 526_ AQPQV 531_ TMQQP 536_ AVHVQ 541_ GQEPL 546_ TASML 551_ ASAPP 556_ QEQKQ 561_ MLGER 566_ LFPLI 571_ QAMHP 576_ TLAGK 581_ ITGML 586_ LEIDN 591_ SELLH 596_ MLESP 601_ ESLRS 606_ KVDEA 611_ VAVLQ 616_ AHQAK 621_ EAAQK 626_ AVNSA 631_TGVPT
1: Binds the poly(A) tail of mRNA, including that of its own transcript, and regulates processes of mRNA metabolism such as pre-mRNA splicing and mRNA stability (PubMed:11051545, PubMed:17212783, PubMed:25480299). Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2 (PubMed:11051545, PubMed:20573744). Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). Involved in translationally coupled mRNA turnover (PubMed:11051545). Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (PubMed:11051545). Involved in regulation of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons; for the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed (PubMed:18447585). By binding to long poly(A) tails, may protect them from uridylation by ZCCHC6/ZCCHC11 and hence contribute to mRNA stability (PubMed:25480299)
2: (Microbial infection) Positively regulates the replication of dengue virus (DENV)