ADP/ATP translocase 1 (ADP,ATP carrier protein 1) (ADP,ATP carrier protein, heart/skeletal muscle isoform T1) (Adenine nucleotide translocator 1) (ANT 1) (Solute carrier family 25 member 4)
1_MGDHA 6_ WSFLK 11_ DFLAG 16_ GVAAA 21_ VSKTA 26_ VAPIE 31_ RVKLL 36_ LQVQH 41_ ASKQI 46_ SAEKQ 51_ YKGII 56_ DCVVR 61_ IPKEQ 66_ GFLSF 71_ WRGNL 76_ ANVIR 81_ YFPTQ 86_ ALNFA 91_ FKDKY 96_ KQLFL 101_ GGVDR 106_ HKQFW 111_ RYFAG 116_ NLASG 121_ GAAGA 126_ TSLCF 131_ VYPLD 136_ FARTR 141_ LAADV 146_ GKGAA 151_ QREFH 156_ GLGDC 161_ IIKIF 166_ KSDGL 171_ RGLYQ 176_ GFNVS 181_ VQGII 186_ IYRAA 191_ YFGVY 196_ DTAKG 201_ MLPDP 206_ KNVHI 211_ FVSWM 216_ IAQSV 221_ TAVAG 226_ LVSYP 231_ FDTVR 236_ RRMMM 241_ QSGRK 246_ GADIM 251_ YTGTV 256_ DCWRK 261_ IAKDE 266_ GAKAF 271_ FKGAW 276_ SNVLR 281_ GMGGA 286_ FVLVL 291_YDEIK
1: ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (PubMed:21586654, PubMed:27693233). Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane (By similarity). In addition to its ADP:ATP antiporter activity, also involved in mitochondrial uncoupling and mitochondrial permeability transition pore (mPTP) activity (PubMed:31883789). Plays a role in mitochondrial uncoupling by acting as a proton transporter: proton transport uncouples the proton flows via the electron transport chain and ATP synthase to reduce the efficiency of ATP production and cause mitochondrial thermogenesis (By similarity). Proton transporter activity is inhibited by ADP:ATP antiporter activity, suggesting that SLC25A4/ANT1 acts as a master regulator of mitochondrial energy output by maintaining a delicate balance between ATP production (ADP:ATP antiporter activity) and thermogenesis (proton transporter activity) (By similarity). Proton transporter activity requires free fatty acids as cofactor, but does not transport it (By similarity). Also plays a key role in mPTP opening, a non-specific pore that enables free passage of the mitochondrial membranes to solutes of up to 1.5 kDa, and which contributes to cell death (PubMed:31883789). It is however unclear if SLC25A4/ANT1 constitutes a pore-forming component of mPTP or regulates it (By similarity). Acts as a regulator of mitophagy independently of ADP:ATP antiporter activity: promotes mitophagy via interaction with TIMM44, leading to inhibit the presequence translocase TIMM23, thereby promoting stabilization of PINK1 (By similarity)