ADP/ATP translocase 3 (ADP,ATP carrier protein 3) (ADP,ATP carrier protein, isoform T2) (ANT 2) (Adenine nucleotide translocator 3) (ANT 3) (Solute carrier family 25 member 6) [Cleaved into: ADP/ATP translocase 3, N-terminally processed]
1_MTEQA 6_ ISFAK 11_ DFLAG 16_ GIAAA 21_ ISKTA 26_ VAPIE 31_ RVKLL 36_ LQVQH 41_ ASKQI 46_ AADKQ 51_ YKGIV 56_ DCIVR 61_ IPKEQ 66_ GVLSF 71_ WRGNL 76_ ANVIR 81_ YFPTQ 86_ ALNFA 91_ FKDKY 96_ KQIFL 101_ GGVDK 106_ HTQFW 111_ RYFAG 116_ NLASG 121_ GAAGA 126_ TSLCF 131_ VYPLD 136_ FARTR 141_ LAADV 146_ GKSGT 151_ EREFR 156_ GLGDC 161_ LVKIT 166_ KSDGI 171_ RGLYQ 176_ GFSVS 181_ VQGII 186_ IYRAA 191_ YFGVY 196_ DTAKG 201_ MLPDP 206_ KNTHI 211_ VVSWM 216_ IAQTV 221_ TAVAG 226_ VVSYP 231_ FDTVR 236_ RRMMM 241_ QSGRK 246_ GADIM 251_ YTGTV 256_ DCWRK 261_ IFRDE 266_ GGKAF 271_ FKGAW 276_ SNVLR 281_ GMGGA 286_ FVLVL 291_YDELK
1: ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (By similarity). Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane (By similarity). In addition to its ADP:ATP antiporter activity, also involved in mitochondrial uncoupling and mitochondrial permeability transition pore (mPTP) activity (PubMed:15033708). Plays a role in mitochondrial uncoupling by acting as a proton transporter: proton transport uncouples the proton flows via the electron transport chain and ATP synthase to reduce the efficiency of ATP production and cause mitochondrial thermogenesis (By similarity). Proton transporter activity is inhibited by ADP:ATP antiporter activity, suggesting that SLC25A6/ANT3 acts as a master regulator of mitochondrial energy output by maintaining a delicate balance between ATP production (ADP:ATP antiporter activity) and thermogenesis (proton transporter activity) (By similarity). Proton transporter activity requires free fatty acids as cofactor, but does not transport it (By similarity). Also plays a key role in mPTP opening, a non-specific pore that enables free passage of the mitochondrial membranes to solutes of up to 1.5 kDa, and which contributes to cell death (PubMed:15033708). It is however unclear if SLC25A6/ANT3 constitutes a pore-forming component of mPTP or regulates it (By similarity)