Inosine-5'-monophosphate dehydrogenase 2 (IMP dehydrogenase 2) (IMPD 2) (IMPDH 2) (EC 1.1.1.205) (Inosine-5'-monophosphate dehydrogenase type II) (IMP dehydrogenase II) (IMPDH-II)
1_MADYL 6_ ISGGT 11_ SYVPD 16_ DGLTA 21_ QQLFN 26_ CGDGL 31_ TYNDF 36_ LILPG 41_ YIDFT 46_ ADQVD 51_ LTSAL 56_ TKKIT 61_ LKTPL 66_ VSSPM 71_ DTVTE 76_ AGMAI 81_ AMALT 86_ GGIGF 91_ IHHNC 96_ TPEFQ 101_ ANEVR 106_ KVKKY 111_ EQGFI 116_ TDPVV 121_ LSPKD 126_ RVRDV 131_ FEAKA 136_ RHGFC 141_ GIPIT 146_ DTGRM 151_ GSRLV 156_ GIISS 161_ RDIDF 166_ LKEEE 171_ HDCFL 176_ EEIMT 181_ KREDL 186_ VVAPA 191_ GITLK 196_ EANEI 201_ LQRSK 206_ KGKLP 211_ IVNED 216_ DELVA 221_ IIART 226_ DLKKN 231_ RDYPL 236_ ASKDA 241_ KKQLL 246_ CGAAI 251_ GTHED 256_ DKYRL 261_ DLLAQ 266_ AGVDV 271_ VVLDS 276_ SQGNS 281_ IFQIN 286_ MIKYI 291_ KDKYP 296_ NLQVI 301_ GGNVV 306_ TAAQA 311_ KNLID 316_ AGVDA 321_ LRVGM 326_ GSGSI 331_ CITQE 336_ VLACG 341_ RPQAT 346_ AVYKV 351_ SEYAR 356_ RFGVP 361_ VIADG 366_ GIQNV 371_ GHIAK 376_ ALALG 381_ ASTVM 386_ MGSLL 391_ AATTE 396_ APGEY 401_ FFSDG 406_ IRLKK 411_ YRGMG 416_ SLDAM 421_ DKHLS 426_ SQNRY 431_ FSEAD 436_ KIKVA 441_ QGVSG 446_ AVQDK 451_ GSIHK 456_ FVPYL 461_ IAGIQ 466_ HSCQD 471_ IGAKS 476_ LTQVR 481_ AMMYS 486_ GELKF 491_ EKRTS 496_ SAQVE 501_ GGVHS 506_LHSYE
1: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (PubMed:7763314, PubMed:7903306). Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism (PubMed:14766016). It may also have a role in the development of malignancy and the growth progression of some tumors