Nucleoprotein TPR (Megator) (NPC-associated intranuclear protein) (Translocated promoter region protein)
1_MAAVL 6_ QQVLE 11_ RTELN 16_ KLPKS 21_ VQNKL 26_ EKFLA 31_ DQQSE 36_ IDGLK 41_ GRHEK 46_ FKVES 51_ EQQYF 56_ EIEKR 61_ LSHSQ 66_ ERLVN 71_ ETREC 76_ QSLRL 81_ ELEKL 86_ NNQLK 91_ ALTEK 96_ NKELE 101_ IAQDR 106_ NIAIQ 111_ SQFTR 116_ TKEEL 121_ EAEKR 126_ DLIRT 131_ NERLS 136_ QELEY 141_ LTEDV 146_ KRLNE 151_ KLKES 156_ NTTKG 161_ ELQLK 166_ LDELQ 171_ ASDVS 176_ VKYRE 181_ KRLEQ 186_ EKELL 191_ HSQNT 196_ WLNTE 201_ LKTKT 206_ DELLA 211_ LGREK 216_ GNEIL 221_ ELKCN 226_ LENKK 231_ EEVSR 236_ LEEQM 241_ NGLKT 246_ SNEHL 251_ QKHVE 256_ DLLTK 261_ LKEAK 266_ EQQAS 271_ MEEKF 276_ HNELN 281_ AHIKL 286_ SNLYK 291_ SAADD 296_ SEAKS 301_ NELTR 306_ AVEEL 311_ HKLLK 316_ EAGEA 321_ NKAIQ 326_ DHLLE 331_ VEQSK 336_ DQMEK 341_ EMLEK 346_ IGRLE 351_ KELEN 356_ ANDLL 361_ SATKR 366_ KGAIL 371_ SEEEL 376_ AAMSP 381_ TAAAV 386_ AKIVK 391_ PGMKL 396_ TELYN 401_ AYVET 406_ QDQLL 411_ LEKLE 416_ NKRIN 421_ KYLDE 426_ IVKEV 431_ EAKAP 436_ ILKRQ 441_ REEYE 446_ RAQKA 451_ VASLS 456_ VKLEQ 461_ AMKEI 466_ QRLQE 471_ DTDKA 476_ NKQSS 481_ VLERD 486_ NRRME 491_ IQVKD 496_ LSQQI 501_ RVLLM 506_ ELEEA 511_ RGNHV 516_ IRDEE 521_ VSSAD 526_ ISSSS 531_ EVISQ 536_ HLVSY 541_ RNIEE 546_ LQQQN 551_ QRLLV 556_ ALREL 561_ GETRE 566_ REEQE 571_ TTSSK 576_ ITELQ 581_ LKLES 586_ ALTEL 591_ EQLRK 596_ SRQHQ 601_ MQLVD 606_ SIVRQ 611_ RDMYR 616_ ILLSQ 621_ TTGVA 626_ IPLHA 631_ SSLDD 636_ VSLAS 641_ TPKRP 646_ STSQT 651_ VSTPA 656_ PVPVI 661_ ESTEA 666_ IEAKA 671_ ALKQL 676_ QEIFE 681_ NYKKE 686_ KAENE 691_ KIQNE 696_ QLEKL 701_ QEQVT 706_ DLRSQ 711_ NTKIS 716_ TQLDF 721_ ASKRY 726_ EMLQD 731_ NVEGY 736_ RREIT 741_ SLHER 746_ NQKLT 751_ ATTQK 756_ QEQII 761_ NTMTQ 766_ DLRGA 771_ NEKLA 776_ VAEVR 781_ AENLK 786_ KEKEM 791_ LKLSE 796_ VRLSQ 801_ QRESL 806_ LAEQR 811_ GQNLL 816_ LTNLQ 821_ TIQGI 826_ LERSE 831_ TETKQ 836_ RLSSQ 841_ IEKLE 846_ HEISH 851_ LKKKL 856_ ENEVE 861_ QRHTL 866_ TRNLD 871_ VQLLD 876_ TKRQL 881_ DTETN 886_ LHLNT 891_ KELLK 896_ NAQKE 901_ IATLK 906_ QHLSN 911_ MEVQV 916_ ASQSS 921_ QRTGK 926_ GQPSN 931_ KEDVD 936_ DLVSQ 941_ LRQTE 946_ EQVND 951_ LKERL 956_ KTSTS 961_ NVEQY 966_ QAMVT 971_ SLEES 976_ LNKEK 981_ QVTEE 986_ VRKNI 991_ EVRLK 996_ ESAEF 1001_ QTQLE 1006_ KKLME 1011_ VEKEK 1016_ QELQD 1021_ DKRRA 1026_ IESME 1031_ QQLSE 1036_ LKKTL 1041_ SSVQN 1046_ EVQEA 1051_ LQRAS 1056_ TALSN 1061_ EQQAR 1066_ RDCQE 1071_ QAKIA 1076_ VEAQN 1081_ KYERE 1086_ LMLHA 1091_ ADVEA 1096_ LQAAK 1101_ EQVSK 1106_ MASVR 1111_ QHLEE 1116_ TTQKA 1121_ ESQLL 1126_ ECKAS 1131_ WEERE 1136_ RMLKD 1141_ EVSKC 1146_ VCRCE 1151_ DLEKQ 1156_ NRLLH 1161_ DQIEK 1166_ LSDKV 1171_ VASVK 1176_ EGVQG 1181_ PLNVS 1186_ LSEEG 1191_ KSQEQ 1196_ ILEIL 1201_ RFIRR 1206_ EKEIA 1211_ ETRFE 1216_ VAQVE 1221_ SLRYR 1226_ QRVEL 1231_ LEREL 1236_ QELQD 1241_ SLNAE 1246_ REKVQ 1251_ VTAKT 1256_ MAQHE 1261_ ELMKK 1266_ TETMN 1271_ VVMET 1276_ NKMLR 1281_ EEKER 1286_ LEQDL 1291_ QQMQA 1296_ KVRKL 1301_ ELDIL 1306_ PLQEA 1311_ NAELS 1316_ EKSGM 1321_ LQAEK 1326_ KLLEE 1331_ DVKRW 1336_ KARNQ 1341_ HLVSQ 1346_ QKDPD 1351_ TEEYR 1356_ KLLSE 1361_ KEVHT 1366_ KRIQQ 1371_ LTEEI 1376_ GRLKA 1381_ EIARS 1386_ NASLT 1391_ NNQNL 1396_ IQSLK 1401_ EDLNK 1406_ VRTEK 1411_ ETIQK 1416_ DLDAK 1421_ IIDIQ 1426_ EKVKT 1431_ ITQVK 1436_ KIGRR 1441_ YKTQY 1446_ EELKA 1451_ QQDKV 1456_ METSA 1461_ QSSGD 1466_ HQEQH 1471_ VSVQE 1476_ MQELK 1481_ ETLNQ 1486_ AETKS 1491_ KSLES 1496_ QVENL 1501_ QKTLS 1506_ EKETE 1511_ ARNLQ 1516_ EQTVQ 1521_ LQSEL 1526_ SRLRQ 1531_ DLQDR 1536_ TTQEE 1541_ QLRQQ 1546_ ITEKE 1551_ EKTRK 1556_ AIVAA 1561_ KSKIA 1566_ HLAGV 1571_ KDQLT 1576_ KENEE 1581_ LKQRN 1586_ GALDQ 1591_ QKDEL 1596_ DVRIT 1601_ ALKSQ 1606_ YEGRI 1611_ SRLER 1616_ ELREH 1621_ QERHL 1626_ EQRDE 1631_ PQEPS 1636_ NKVPE 1641_ QQRQI 1646_ TLKTT 1651_ PASGE 1656_ RGIAS 1661_ TSDPP 1666_ TANIK 1671_ PTPVV 1676_ STPSK 1681_ VTAAA 1686_ MAGNK 1691_ STPRA 1696_ SIRPM 1701_ VTPAT 1706_ VTNPT 1711_ TTPTA 1716_ TVMPT 1721_ TQVES 1726_ QEAMQ 1731_ SEGPV 1736_ EHVPV 1741_ FGSTS 1746_ GSVRS 1751_ TSPNV 1756_ QPSIS 1761_ QPILT 1766_ VQQQT 1771_ QATAF 1776_ VQPTQ 1781_ QSHPQ 1786_ IEPAN 1791_ QELSS 1796_ NIVEV 1801_ VQSSP 1806_ VERPS 1811_ TSTAV 1816_ FGTVS 1821_ ATPSS 1826_ SLPKR 1831_ TREEE 1836_ EDSTI 1841_ EASDQ 1846_ VSDDT 1851_ VEMPL 1856_ PKKLK 1861_ SVTPV 1866_ GTEEE 1871_ VMAEE 1876_ STDGE 1881_ VETQV 1886_ YNQDS 1891_ QDSIG 1896_ EGVTQ 1901_ GDYTP 1906_ MEDSE 1911_ ETSQS 1916_ LQIDL 1921_ GPLQS 1926_ DQQTT 1931_ TSSQD 1936_ GQGKG 1941_ DDVIV 1946_ IDSDD 1951_ EEEDD 1956_ DENDG 1961_ EHEDY 1966_ EEDEE 1971_ DDDDD 1976_ EDDTG 1981_ MGDEG 1986_ EDSNE 1991_ GTGSA 1996_ DGNDG 2001_ YEADD 2006_ AEGGD 2011_ GTDPG 2016_ TETEE 2021_ SMGGG 2026_ EGNHR 2031_ AADSQ 2036_ NSGEG 2041_ NTGAA 2046_ ESSFS 2051_ QEVSR 2056_ EQQPS 2061_ SASER 2066_ QAPRA 2071_ PQSPR 2076_ RPPHP 2081_ LPPRL 2086_ TIHAP 2091_ PQELG 2096_ PPVQR 2101_ IQMTR 2106_ RQSVG 2111_ RGLQL 2116_ TPGIG 2121_ GMQQH 2126_ FFDDE 2131_ DRTVP 2136_ STPTL 2141_ VVPHR 2146_ TDGFA 2151_ EAIHS 2156_ PQVAG 2161_ VPRFR 2166_ FGPPE 2171_ DMPQT 2176_ SSSHS 2181_ DLGQL 2186_ ASQGG 2191_ LGMYE 2196_ TPLFL 2201_ AHEEE 2206_ SGGRS 2211_ VPTTP 2216_ LQVAA 2221_ PVTVF 2226_ TESTT 2231_ SDASE 2236_ HASQS 2241_ VPMVT 2246_ TSTGT 2251_ LSTTN 2256_ ETATG 2261_ DDGDE 2266_ VFVEA 2271_ ESEGI 2276_ SSEAG 2281_ LEIDS 2286_ QQEEE 2291_ PVQAS 2296_ DESDL 2301_ PSTSQ 2306_ DPPSS 2311_ SSVDT 2316_ SSSQP 2321_ KPFRR 2326_ VRLQT 2331_ TLRQG 2336_ VRGRQ 2341_ FNRQR 2346_ GVSHA 2351_ MGGRG 2356_GINRG
1: Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced conditions. Modulates the nucleocytoplasmic transport of activated MAPK1/ERK2 and huntingtin/HTT and may serve as a docking site for the XPO1/CRM1-mediated nuclear export complex. According to some authors, plays a limited role in the regulation of nuclear protein export (PubMed:11952838, PubMed:22253824). Also plays a role as a structural and functional element of the perinuclear chromatin distribution; involved in the formation and/or maintenance of NPC-associated perinuclear heterochromatin exclusion zones (HEZs). Finally, acts as a spatial regulator of the spindle-assembly checkpoint (SAC) response ensuring a timely and effective recruitment of spindle checkpoint proteins like MAD1L1 and MAD2L1 to unattached kinetochore during the metaphase-anaphase transition before chromosome congression. Its N-terminus is involved in activation of oncogenic kinases