Creatine kinase B-type (EC 2.7.3.2) (Brain creatine kinase) (B-CK) (Creatine kinase B chain) (Creatine phosphokinase B-type) (CPK-B)
1_MPFSN 6_ SHNAL 11_ KLRFP 16_ AEDEF 21_ PDLSA 26_ HNNHM 31_ AKVLT 36_ PELYA 41_ ELRAK 46_ STPSG 51_ FTLDD 56_ VIQTG 61_ VDNPG 66_ HPYIM 71_ TVGCV 76_ AGDEE 81_ SYEVF 86_ KDLFD 91_ PIIED 96_ RHGGY 101_ KPSDE 106_ HKTDL 111_ NPDNL 116_ QGGDD 121_ LDPNY 126_ VLSSR 131_ VRTGR 136_ SIRGF 141_ CLPPH 146_ CSRGE 151_ RRAIE 156_ KLAVE 161_ ALSSL 166_ DGDLA 171_ GRYYA 176_ LKSMT 181_ EAEQQ 186_ QLIDD 191_ HFLFD 196_ KPVSP 201_ LLLAS 206_ GMARD 211_ WPDAR 216_ GIWHN 221_ DNKTF 226_ LVWVN 231_ EEDHL 236_ RVISM 241_ QKGGN 246_ MKEVF 251_ TRFCT 256_ GLTQI 261_ ETLFK 266_ SKDYE 271_ FMWNP 276_ HLGYI 281_ LTCPS 286_ NLGTG 291_ LRAGV 296_ HIKLP 301_ NLGKH 306_ EKFSE 311_ VLKRL 316_ RLQKR 321_ GTGGV 326_ DTAAV 331_ GGVFD 336_ VSNAD 341_ RLGFS 346_ EVELV 351_ QMVVD 356_ GVKLL 361_ IEMEQ 366_ RLEQG 371_ QAIDD 376_LMPAQ
1: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate) (PubMed:8186255). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (Probable). Acts as a key regulator of adaptive thermogenesis as part of the futile creatine cycle: localizes to the mitochondria of thermogenic fat cells and acts by mediating phosphorylation of creatine to initiate a futile cycle of creatine phosphorylation and dephosphorylation (By similarity). During the futile creatine cycle, creatine and N-phosphocreatine are in a futile cycle, which dissipates the high energy charge of N-phosphocreatine as heat without performing any mechanical or chemical work (By similarity)