High affinity immunoglobulin epsilon receptor subunit alpha (Fc-epsilon RI-alpha) (FcERI) (IgE Fc receptor subunit alpha)
1_MAPAM 6_ ESPTL 11_ LCVAL 16_ LFFAP 21_ DGVLA 26_ VPQKP 31_ KVSLN 36_ PPWNR 41_ IFKGE 46_ NVTLT 51_ CNGNN 56_ FFEVS 61_ STKWF 66_ HNGSL 71_ SEETN 76_ SSLNI 81_ VNAKF 86_ EDSGE 91_ YKCQH 96_ QQVNE 101_ SEPVY 106_ LEVFS 111_ DWLLL 116_ QASAE 121_ VVMEG 126_ QPLFL 131_ RCHGW 136_ RNWDV 141_ YKVIY 146_ YKDGE 151_ ALKYW 156_ YENHN 161_ ISITN 166_ ATVED 171_ SGTYY 176_ CTGKV 181_ WQLDY 186_ ESEPL 191_ NITVI 196_ KAPRE 201_ KYWLQ 206_ FFIPL 211_ LVVIL 216_ FAVDT 221_ GLFIS 226_ TQQQV 231_ TFLLK 236_ IKRTR 241_ KGFRL 246_ LNPHP 251_KPNPK
1: High-affinity receptor for immunoglobulin epsilon/IgE. Mediates IgE effector functions in myeloid cells. Upon IgE binding and antigen/allergen cross-linking initiates signaling pathways that lead to myeloid cell activation and differentiation. On mast cells, basophils and eosinophils stimulates the secretion of vasoactive amines, lipid mediators and cytokines that contribute to inflammatory response, tissue remodeling and cytotoxicity against microbes. Triggers the immediate hypersensitivity response to allergens as a host defense mechanism against helminth parasites, pathogenic bacteria and venom toxicity. When dysregulated, it can elicit harmful life-threatening allergic and anaphylactic reactions