Bone morphogenetic protein 3 (BMP-3) (Bone morphogenetic protein 3A) (BMP-3A) (Osteogenin)
1_MAGAS 6_ RLLFL 11_ WLGCF 16_ CVSLA 21_ QGERP 26_ KPPFP 31_ ELRKA 36_ VPGDR 41_ TAGGG 46_ PDSEL 51_ QPQDK 56_ VSEHM 61_ LRLYD 66_ RYSTV 71_ QAART 76_ PGSLE 81_ GGSQP 86_ WRPRL 91_ LREGN 96_ TVRSF 101_ RAAAA 106_ ETLER 111_ KGLYI 116_ FNLTS 121_ LTKSE 126_ NILSA 131_ TLYFC 136_ IGELG 141_ NISLS 146_ CPVSG 151_ GCSHH 156_ AQRKH 161_ IQIDL 166_ SAWTL 171_ KFSRN 176_ QSQLL 181_ GHLSV 186_ DMAKS 191_ HRDIM 196_ SWLSK 201_ DITQL 206_ LRKAK 211_ ENEEF 216_ LIGFN 221_ ITSKG 226_ RQLPK 231_ RRLPF 236_ PEPYI 241_ LVYAN 246_ DAAIS 251_ EPESV 256_ VSSLQ 261_ GHRNF 266_ PTGTV 271_ PKWDS 276_ HIRAA 281_ LSIER 286_ RKKRS 291_ TGVLL 296_ PLQNN 301_ ELPGA 306_ EYQYK 311_ KDEVW 316_ EERKP 321_ YKTLQ 326_ AQAPE 331_ KSKNK 336_ KKQRK 341_ GPHRK 346_ SQTLQ 351_ FDEQT 356_ LKKAR 361_ RKQWI 366_ EPRNC 371_ ARRYL 376_ KVDFA 381_ DIGWS 386_ EWIIS 391_ PKSFD 396_ AYYCS 401_ GACQF 406_ PMPKS 411_ LKPSN 416_ HATIQ 421_ SIVRA 426_ VGVVP 431_ GIPEP 436_ CCVPE 441_ KMSSL 446_ SILFF 451_ DENKN 456_ VVLKV 461_ YPNMT 466_VESCA
1: Growth factor of the TGF-beta superfamily that plays an essential role in developmental process by inducing and patterning early skeletal formation and by negatively regulating bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentiation and ossification (PubMed:11138004, PubMed:15269709). Initiates signaling cascades by associating with type II receptor ACVR2B to activate SMAD2-dependent and SMAD-independent signaling cascades including TAK1 and JNK pathways (PubMed:31665064)