Eosinophil cationic protein (ECP) (EC 3.1.27.-) (Ribonuclease 3) (RNase 3)
1_MVPKL 6_ FTSQI 11_ CLLLL 16_ LGLMG 21_ VEGSL 26_ HARPP 31_ QFTRA 36_ QWFAI 41_ QHISL 46_ NPPRC 51_ TIAMR 56_ AINNY 61_ RWRCK 66_ NQNTF 71_ LRTTF 76_ ANVVN 81_ VCGNQ 86_ SIRCP 91_ HNRTL 96_ NNCHR 101_ SRFRV 106_ PLLHC 111_ DLINP 116_ GAQNI 121_ SNCTY 126_ ADRPG 131_ RRFYV 136_ VACDN 141_ RDPRD 146_ SPRYP 151_VVPVH
1: Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of biological activities. Exhibits antibacterial activity, including cytoplasmic membrane depolarization of preferentially Gram-negative, but also Gram-positive strains. Promotes E.coli outer membrane detachment, alteration of the overall cell shape and partial loss of cell content