Cadherin-1 (CAM 120/80) (Epithelial cadherin) (E-cadherin) (Uvomorulin) (CD antigen CD324) [Cleaved into: E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3]
1_MGPWS 6_ RSLSA 11_ LLLLL 16_ QVSSW 21_ LCQEP 26_ EPCHP 31_ GFDAE 36_ SYTFT 41_ VPRRH 46_ LERGR 51_ VLGRV 56_ NFEDC 61_ TGRQR 66_ TAYFS 71_ LDTRF 76_ KVGTD 81_ GVITV 86_ KRPLR 91_ FHNPQ 96_ IHFLV 101_ YAWDS 106_ TYRKF 111_ STKVT 116_ LNTVG 121_ HHHRP 126_ PPHQA 131_ SVSGI 136_ QAELL 141_ TFPNS 146_ SPGLR 151_ RQKRD 156_ WVIPP 161_ ISCPE 166_ NEKGP 171_ FPKNL 176_ VQIKS 181_ NKDKE 186_ GKVFY 191_ SITGQ 196_ GADTP 201_ PVGVF 206_ IIERE 211_ TGWLK 216_ VTEPL 221_ DRERI 226_ ATYTL 231_ FSHAV 236_ SSNGN 241_ AVEDP 246_ MEILI 251_ TVTDQ 256_ NDNKP 261_ EFTQE 266_ VFKGS 271_ VMEGA 276_ LPGTS 281_ VMEVT 286_ ATDAD 291_ DDVNT 296_ YNAAI 301_ AYTIL 306_ SQDPE 311_ LPDKN 316_ MFTIN 321_ RNTGV 326_ ISVVT 331_ TGLDR 336_ ESFPT 341_ YTLVV 346_ QAADL 351_ QGEGL 356_ STTAT 361_ AVITV 366_ TDTND 371_ NPPIF 376_ NPTTY 381_ KGQVP 386_ ENEAN 391_ VVITT 396_ LKVTD 401_ ADAPN 406_ TPAWE 411_ AVYTI 416_ LNDDG 421_ GQFVV 426_ TTNPV 431_ NNDGI 436_ LKTAK 441_ GLDFE 446_ AKQQY 451_ ILHVA 456_ VTNVV 461_ PFEVS 466_ LTTST 471_ ATVTV 476_ DVLDV 481_ NEAPI 486_ FVPPE 491_ KRVEV 496_ SEDFG 501_ VGQEI 506_ TSYTA 511_ QEPDT 516_ FMEQK 521_ ITYRI 526_ WRDTA 531_ NWLEI 536_ NPDTG 541_ AISTR 546_ AELDR 551_ EDFEH 556_ VKNST 561_ YTALI 566_ IATDN 571_ GSPVA 576_ TGTGT 581_ LLLIL 586_ SDVND 591_ NAPIP 596_ EPRTI 601_ FFCER 606_ NPKPQ 611_ VINII 616_ DADLP 621_ PNTSP 626_ FTAEL 631_ THGAS 636_ ANWTI 641_ QYNDP 646_ TQESI 651_ ILKPK 656_ MALEV 661_ GDYKI 666_ NLKLM 671_ DNQNK 676_ DQVTT 681_ LEVSV 686_ CDCEG 691_ AAGVC 696_ RKAQP 701_ VEAGL 706_ QIPAI 711_ LGILG 716_ GILAL 721_ LILIL 726_ LLLLF 731_ LRRRA 736_ VVKEP 741_ LLPPE 746_ DDTRD 751_ NVYYY 756_ DEEGG 761_ GEEDQ 766_ DFDLS 771_ QLHRG 776_ LDARP 781_ EVTRN 786_ DVAPT 791_ LMSVP 796_ RYLPR 801_ PANPD 806_ EIGNF 811_ IDENL 816_ KAADT 821_ DPTAP 826_ PYDSL 831_ LVFDY 836_ EGSGS 841_ EAASL 846_ SSLNS 851_ SESDK 856_ DQDYD 861_ YLNEW 866_ GNRFK 871_ KLADM 876_YGGGE
1: Cadherins are calcium-dependent cell adhesion proteins (PubMed:11976333). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells (PubMed:11976333). Promotes organization of radial actin fiber structure and cellular response to contractile forces, via its interaction with AMOTL2 which facilitates anchoring of radial actin fibers to CDH1 junction complexes at the cell membrane (By similarity). Plays a role in the early stages of desmosome cell-cell junction formation via facilitating the recruitment of DSG2 and DSP to desmosome plaques (PubMed:29999492). Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7
2: E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production
3: (Microbial infection) Serves as a receptor for Listeria monocytogenes; internalin A (InlA) binds to this protein and promotes uptake of the bacteria