X-ray repair cross-complementing protein 6 (EC 3.6.4.-) (EC 4.2.99.-) (5'-deoxyribose-5-phosphate lyase Ku70) (5'-dRP lyase Ku70) (70 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 1) (ATP-dependent DNA helicase II 70 kDa subunit) (CTC box-binding factor 75 kDa subunit) (CTC75) (CTCBF) (DNA repair protein XRCC6) (Lupus Ku autoantigen protein p70) (Ku70) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 6)
1_MSGWE 6_ SYYKT 11_ EGDEE 16_ AEEEQ 21_ EENLE 26_ ASGDY 31_ KYSGR 36_ DSLIF 41_ LVDAS 46_ KAMFE 51_ SQSED 56_ ELTPF 61_ DMSIQ 66_ CIQSV 71_ YISKI 76_ ISSDR 81_ DLLAV 86_ VFYGT 91_ EKDKN 96_ SVNFK 101_ NIYVL 106_ QELDN 111_ PGAKR 116_ ILELD 121_ QFKGQ 126_ QGQKR 131_ FQDMM 136_ GHGSD 141_ YSLSE 146_ VLWVC 151_ ANLFS 156_ DVQFK 161_ MSHKR 166_ IMLFT 171_ NEDNP 176_ HGNDS 181_ AKASR 186_ ARTKA 191_ GDLRD 196_ TGIFL 201_ DLMHL 206_ KKPGG 211_ FDISL 216_ FYRDI 221_ ISIAE 226_ DEDLR 231_ VHFEE 236_ SSKLE 241_ DLLRK 246_ VRAKE 251_ TRKRA 256_ LSRLK 261_ LKLNK 266_ DIVIS 271_ VGIYN 276_ LVQKA 281_ LKPPP 286_ IKLYR 291_ ETNEP 296_ VKTKT 301_ RTFNT 306_ STGGL 311_ LLPSD 316_ TKRSQ 321_ IYGSR 326_ QIILE 331_ KEETE 336_ ELKRF 341_ DDPGL 346_ MLMGF 351_ KPLVL 356_ LKKHH 361_ YLRPS 366_ LFVYP 371_ EESLV 376_ IGSST 381_ LFSAL 386_ LIKCL 391_ EKEVA 396_ ALCRY 401_ TPRRN 406_ IPPYF 411_ VALVP 416_ QEEEL 421_ DDQKI 426_ QVTPP 431_ GFQLV 436_ FLPFA 441_ DDKRK 446_ MPFTE 451_ KIMAT 456_ PEQVG 461_ KMKAI 466_ VEKLR 471_ FTYRS 476_ DSFEN 481_ PVLQQ 486_ HFRNL 491_ EALAL 496_ DLMEP 501_ EQAVD 506_ LTLPK 511_ VEAMN 516_ KRLGS 521_ LVDEF 526_ KELVY 531_ PPDYN 536_ PEGKV 541_ TKRKH 546_ DNEGS 551_ GSKRP 556_ KVEYS 561_ EEELK 566_ THISK 571_ GTLGK 576_ FTVPM 581_ LKEAC 586_ RAYGL 591_ KSGLK 596_ KQELL 601_EALTK
1: Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Required for double-strand break repair and V(D)J recombination (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Also has a role in chromosome translocation (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Has a role in chromosome translocation (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). It works in the 3'-5' direction (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). During NHEJ, the XRCC5-XRRC6 dimer performs the recognition step: it recognizes and binds to the broken ends of the DNA and protects them from further resection (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Binding to DNA may be mediated by XRCC6 (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The XRCC5-XRRC6 dimer acts as a regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The XRCC5-XRRC6 dimer is probably involved in stabilizing broken DNA ends and bringing them together (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks (PubMed:20383123). 5'-dRP lyase activity allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined (PubMed:20383123). The XRCC5-XRRC6 dimer together with APEX1 acts as a negative regulator of transcription (PubMed:8621488). In association with NAA15, the XRCC5-XRRC6 dimer binds to the osteocalcin promoter and activates osteocalcin expression (PubMed:12145306). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Negatively regulates apoptosis by interacting with BAX and sequestering it from the mitochondria (PubMed:15023334). Might have deubiquitination activity, acting on BAX (PubMed:18362350)