Nuclear receptor subfamily 2 group C member 1 (Orphan nuclear receptor TR2) (Testicular receptor 2)
1_MATIE 6_ EIAHQ 11_ IIEQQ 16_ MGEIV 21_ TEQQT 26_ GQKIQ 31_ IVTAL 36_ DHNTQ 41_ GKQFI 46_ LTNHD 51_ GSTPS 56_ KVILA 61_ RQDST 66_ PGKVF 71_ LTTPD 76_ AAGVN 81_ QLFFT 86_ TPDLS 91_ AQHLQ 96_ LLTDN 101_ SPDQG 106_ PNKVF 111_ DLCVV 116_ CGDKA 121_ SGRHY 126_ GAVTC 131_ EGCKG 136_ FFKRS 141_ IRKNL 146_ VYSCR 151_ GSKDC 156_ IINKH 161_ HRNRC 166_ QYCRL 171_ QRCIA 176_ FGMKQ 181_ DSVQC 186_ ERKPI 191_ EVSRE 196_ KSSNC 201_ AASTE 206_ KIYIR 211_ KDLRS 216_ PLTAT 221_ PTFVT 226_ DSEST 231_ RSTGL 236_ LDSGM 241_ FMNIH 246_ PSGVK 251_ TESAV 256_ LMTSD 261_ KAESC 266_ QGDLS 271_ TLANV 276_ VTSLA 281_ NLGKT 286_ KDLSQ 291_ NSNEM 296_ SMIES 301_ LSNDD 306_ TSLCE 311_ FQEMQ 316_ TNGDV 321_ SRAFD 326_ TLAKA 331_ LNPGE 336_ STACQ 341_ SSVAG 346_ MEGSV 351_ HLITG 356_ DSSIN 361_ YTEKE 366_ GPLLS 371_ DSHVA 376_ FRLTM 381_ PSPMP 386_ EYLNV 391_ HYIGE 396_ SASRL 401_ LFLSM 406_ HWALS 411_ IPSFQ 416_ ALGQE 421_ NSISL 426_ VKAYW 431_ NELFT 436_ LGLAQ 441_ CWQVM 446_ NVATI 451_ LATFV 456_ NCLHN 461_ SLQQD 466_ KMSTE 471_ RRKLL 476_ MEHIF 481_ KLQEF 486_ CNSMV 491_ KLCID 496_ GYEYA 501_ YLKAI 506_ VLFSP 511_ DHPSL 516_ ENMEQ 521_ IEKFQ 526_ EKAYV 531_ EFQDY 536_ ITKTY 541_ PDDTY 546_ RLSRL 551_ LLRLP 556_ ALRLM 561_ NATIT 566_ EELFF 571_ KGLIG 576_ NIRID 581_ SVIPH 586_ ILKME 591_ PADYN 596_SQIIG
1: Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Also activator of OCT4 gene expression. May be involved in stem cell proliferation and differentiation. Mediator of retinoic acid-regulated preadipocyte proliferation