Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (Cytochrome c oxidase polypeptide IV) (Cytochrome c oxidase subunit IV isoform 1) (COX IV-1)
1_MLATR 6_ VFSLV 11_ GKRAI 16_ STSVC 21_ VRAHE 26_ SVVKS 31_ EDFSL 36_ PAYMD 41_ RRDHP 46_ LPEVA 51_ HVKHL 56_ SASQK 61_ ALKEK 66_ EKASW 71_ SSLSM 76_ DEKVE 81_ LYRIK 86_ FKESF 91_ AEMNR 96_ GSNEW 101_ KTVVG 106_ GAMFF 111_ IGFTA 116_ LVIMW 121_ QKHYV 126_ YGPLP 131_ QSFDK 136_ EWVAK 141_ QTKRM 146_ LDMKV 151_ NPIQG 156_ LASKW 161_DYEKN
1: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix