Interleukin-7 (IL-7)
1_MFHVS 6_ FRYIF 11_ GLPPL 16_ ILVLL 21_ PVASS 26_ DCDIE 31_ GKDGK 36_ QYESV 41_ LMVSI 46_ DQLLD 51_ SMKEI 56_ GSNCL 61_ NNEFN 66_ FFKRH 71_ ICDAN 76_ KEGMF 81_ LFRAA 86_ RKLRQ 91_ FLKMN 96_ STGDF 101_ DLHLL 106_ KVSEG 111_ TTILL 116_ NCTGQ 121_ VKGRK 126_ PAALG 131_ EAQPT 136_ KSLEE 141_ NKSLK 146_ EQKKL 151_ NDLCF 156_ LKRLL 161_ QEIKT 166_ CWNKI 171_LMGTK
1: Hematopoietic cytokine that plays an essential role in the development, expansion, and survival of naive and memory T-cells and B-cells thereby regulating the number of mature lymphocytes and maintaining lymphoid homeostasis (PubMed:25870237, PubMed:7527823). Mechanistically, exerts its biological effects through a receptor composed of IL7RA subunit and the cytokine receptor common subunit gamma/CSF2RG (PubMed:8128231). Binding to the receptor leads to activation of various kinases including JAK1 or JAK3 depending on the cell type and subsequently propagation of signals through activation of several downstream signaling pathways including the PI3K/Akt/mTOR or the JAK-STAT5 (PubMed:18523275, PubMed:20974963)