Gamma-interferon-inducible lysosomal thiol reductase (EC 1.8.-.-) (Gamma-interferon-inducible protein IP-30) (Legumaturain)
1_MTLSP 6_ LLLFL 11_ PPLLL 16_ LLDVP 21_ TAAVQ 26_ ASPLQ 31_ ALDFF 36_ GNGPP 41_ VNYKT 46_ GNLYL 51_ RGPLK 56_ KSNAP 61_ LVNVT 66_ LYYEA 71_ LCGGC 76_ RAFLI 81_ RELFP 86_ TWLLV 91_ MEILN 96_ VTLVP 101_ YGNAQ 106_ EQNVS 111_ GRWEF 116_ KCQHG 121_ EEECK 126_ FNKVE 131_ ACVLD 136_ ELDME 141_ LAFLT 146_ IVCME 151_ EFEDM 156_ ERSLP 161_ LCLQL 166_ YAPGL 171_ SPDTI 176_ MECAM 181_ GDRGM 186_ QLMHA 191_ NAQRT 196_ DALQP 201_ PHEYV 206_ PWVTV 211_ NGKPL 216_ EDQTQ 221_ LLTLV 226_ CQLYQ 231_ GKKPD 236_ VCPSS 241_TSSLR
1: Lysosomal thiol reductase that can reduce protein disulfide bonds. May facilitate the complete unfolding of proteins destined for lysosomal degradation. Plays an important role in antigen processing. Facilitates the generation of MHC class II-restricted epitodes from disulfide bond-containing antigen by the endocytic reduction of disulfide bonds (By similarity). Also facilitates MHC class I-restricted recognition of exogenous antigens containing disulfide bonds by CD8+ T-cells or crosspresentation (By similarity)