Teratocarcinoma-derived growth factor 1 (Cripto-1 growth factor) (CRGF) (Epidermal growth factor-like cripto protein CR1)
1_MDCRK 6_ MARFS 11_ YSVIW 16_ IMAIS 21_ KVFEL 26_ GLVAG 31_ LGHQE 36_ FARPS 41_ RGYLA 46_ FRDDS 51_ IWPQE 56_ EPAIR 61_ PRSSQ 66_ RVPPM 71_ GIQHS 76_ KELNR 81_ TCCLN 86_ GGTCM 91_ LGSFC 96_ ACPPS 101_ FYGRN 106_ CEHDV 111_ RKENC 116_ GSVPH 121_ DTWLP 126_ KKCSL 131_ CKCWH 136_ GQLRC 141_ FPQAF 146_ LPGCD 151_ GLVMD 156_ EHLVA 161_ SRTPE 166_ LPPSA 171_ RTTTF 176_ MLVGI 181_CLSIQ
1: GPI-anchored cell membrane protein involved in Nodal signaling. Cell-associated CRIPTO acts as a Nodal coreceptor in cis. Shedding of CRIPTO by TMEM8A modulates Nodal signaling by allowing soluble CRIPTO to act as a Nodal coreceptor on other cells (PubMed:27881714). Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm (PubMed:11909953)