Lysosome-associated membrane glycoprotein 2 (LAMP-2) (Lysosome-associated membrane protein 2) (CD107 antigen-like family member B) (LGP-96) (CD antigen CD107b)
1_MVCFR 6_ LFPVP 11_ GSGLV 16_ LVCLV 21_ LGAVR 26_ SYALE 31_ LNLTD 36_ SENAT 41_ CLYAK 46_ WQMNF 51_ TVRYE 56_ TTNKT 61_ YKTVT 66_ ISDHG 71_ TVTYN 76_ GSICG 81_ DDQNG 86_ PKIAV 91_ QFGPG 96_ FSWIA 101_ NFTKA 106_ ASTYS 111_ IDSVS 116_ FSYNT 121_ GDNTT 126_ FPDAE 131_ DKGIL 136_ TVDEL 141_ LAIRI 146_ PLNDL 151_ FRCNS 156_ LSTLE 161_ KNDVV 166_ QHYWD 171_ VLVQA 176_ FVQNG 181_ TVSTN 186_ EFLCD 191_ KDKTS 196_ TVAPT 201_ IHTTV 206_ PSPTT 211_ TPTPK 216_ EKPEA 221_ GTYSV 226_ NNGND 231_ TCLLA 236_ TMGLQ 241_ LNITQ 246_ DKVAS 251_ VININ 256_ PNTTH 261_ STGSC 266_ RSHTA 271_ LLRLN 276_ SSTIK 281_ YLDFV 286_ FAVKN 291_ ENRFY 296_ LKEVN 301_ ISMYL 306_ VNGSV 311_ FSIAN 316_ NNLSY 321_ WDAPL 326_ GSSYM 331_ CNKEQ 336_ TVSVS 341_ GAFQI 346_ NTFDL 351_ RVQPF 356_ NVTQG 361_ KYSTA 366_ QDCSA 371_ DDDNF 376_ LVPIA 381_ VGAAL 386_ AGVLI 391_ LVLLA 396_ YFIGL 401_KHHHA
1: Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, lysosomal pH regulation and autophagy (PubMed:11082038, PubMed:18644871, PubMed:24880125, PubMed:27628032, PubMed:36586411, PubMed:37390818, PubMed:8662539). Acts as an important regulator of lysosomal lumen pH regulation by acting as a direct inhibitor of the proton channel TMEM175, facilitating lysosomal acidification for optimal hydrolase activity (PubMed:37390818). Plays an important role in chaperone-mediated autophagy, a process that mediates lysosomal degradation of proteins in response to various stresses and as part of the normal turnover of proteins with a long biological half-live (PubMed:11082038, PubMed:18644871, PubMed:24880125, PubMed:27628032, PubMed:36586411, PubMed:8662539). Functions by binding target proteins, such as GAPDH, NLRP3 and MLLT11, and targeting them for lysosomal degradation (PubMed:11082038, PubMed:18644871, PubMed:24880125, PubMed:36586411, PubMed:8662539). In the chaperone-mediated autophagy, acts downstream of chaperones, such as HSPA8/HSC70, which recognize and bind substrate proteins and mediate their recruitment to lysosomes, where target proteins bind LAMP2 (PubMed:36586411). Plays a role in lysosomal protein degradation in response to starvation (By similarity). Required for the fusion of autophagosomes with lysosomes during autophagy (PubMed:27628032). Cells that lack LAMP2 express normal levels of VAMP8, but fail to accumulate STX17 on autophagosomes, which is the most likely explanation for the lack of fusion between autophagosomes and lysosomes (PubMed:27628032). Required for normal degradation of the contents of autophagosomes (PubMed:27628032). Required for efficient MHC class II-mediated presentation of exogenous antigens via its function in lysosomal protein degradation; antigenic peptides generated by proteases in the endosomal/lysosomal compartment are captured by nascent MHC II subunits (PubMed:15894275, PubMed:20518820). Is not required for efficient MHC class II-mediated presentation of endogenous antigens (PubMed:20518820)
2: Modulates chaperone-mediated autophagy. Decreases presentation of endogenous antigens by MHCII. Does not play a role in the presentation of exogenous and membrane-derived antigens by MHCII
3: (Microbial infection) Supports the FURIN-mediated cleavage of mumps virus fusion protein F by interacting with both FURIN and the unprocessed form but not the processed form of the viral protein F