Ribonuclease inhibitor (Placental ribonuclease inhibitor) (Placental RNase inhibitor) (Ribonuclease/angiogenin inhibitor 1) (RAI)
1_MSLDI 6_ QSLDI 11_ QCEEL 16_ SDARW 21_ AELLP 26_ LLQQC 31_ QVVRL 36_ DDCGL 41_ TEARC 46_ KDISS 51_ ALRVN 56_ PALAE 61_ LNLRS 66_ NELGD 71_ VGVHC 76_ VLQGL 81_ QTPSC 86_ KIQKL 91_ SLQNC 96_ CLTGA 101_ GCGVL 106_ SSTLR 111_ TLPTL 116_ QELHL 121_ SDNLL 126_ GDAGL 131_ QLLCE 136_ GLLDP 141_ QCRLE 146_ KLQLE 151_ YCSLS 156_ AASCE 161_ PLASV 166_ LRAKP 171_ DFKEL 176_ TVSNN 181_ DINEA 186_ GVRVL 191_ CQGLK 196_ DSPCQ 201_ LEALK 206_ LESCG 211_ VTSDN 216_ CRDLC 221_ GIVAS 226_ KASLR 231_ ELALG 236_ SNKLG 241_ DVGMA 246_ ELCPG 251_ LLHPS 256_ SRLRT 261_ LWIWE 266_ CGITA 271_ KGCGD 276_ LCRVL 281_ RAKES 286_ LKELS 291_ LAGNE 296_ LGDEG 301_ ARLLC 306_ ETLLE 311_ PGCQL 316_ ESLWV 321_ KSCSF 326_ TAACC 331_ SHFSS 336_ VLAQN 341_ RFLLE 346_ LQISN 351_ NRLED 356_ AGVRE 361_ LCQGL 366_ GQPGS 371_ VLRVL 376_ WLADC 381_ DVSDS 386_ SCSSL 391_ AATLL 396_ ANHSL 401_ RELDL 406_ SNNCL 411_ GDAGI 416_ LQLVE 421_ SVRQP 426_ GCLLE 431_ QLVLY 436_ DIYWS 441_ EEMED 446_ RLQAL 451_ EKDKP 456_SLRVI
1: Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and angiogenin (ANG) (PubMed:12578357, PubMed:14515218, PubMed:3219362, PubMed:3243277, PubMed:3470787, PubMed:9050852). May play a role in redox homeostasis (PubMed:17292889). Required to inhibit the cytotoxic tRNA ribonuclease activity of ANG in the cytoplasm in absence of stress (PubMed:23843625, PubMed:32510170). Relocates to the nucleus in response to stress, relieving inhibition of ANG in the cytoplasm, and inhibiting the angiogenic activity of ANG in the nucleus (PubMed:23843625)