Bone morphogenetic protein 1 (BMP-1) (EC 3.4.24.19) (Mammalian tolloid protein) (mTld) (Procollagen C-proteinase) (PCP)
1_MPGVA 6_ RLPLL 11_ LGLLL 16_ LPRPG 21_ RPLDL 26_ ADYTY 31_ DLAEE 36_ DDSEP 41_ LNYKD 46_ PCKAA 51_ AFLGD 56_ IALDE 61_ EDLRA 66_ FQVQQ 71_ AVDLR 76_ RHTAR 81_ KSSIK 86_ AAVPG 91_ NTSTP 96_ SCQST 101_ NGQPQ 106_ RGACG 111_ RWRGR 116_ SRSRR 121_ AATSR 126_ PERVW 131_ PDGVI 136_ PFVIG 141_ GNFTG 146_ SQRAV 151_ FRQAM 156_ RHWEK 161_ HTCVT 166_ FLERT 171_ DEDSY 176_ IVFTY 181_ RPCGC 186_ CSYVG 191_ RRGGG 196_ PQAIS 201_ IGKNC 206_ DKFGI 211_ VVHEL 216_ GHVVG 221_ FWHEH 226_ TRPDR 231_ DRHVS 236_ IVREN 241_ IQPGQ 246_ EYNFL 251_ KMEPQ 256_ EVESL 261_ GETYD 266_ FDSIM 271_ HYARN 276_ TFSRG 281_ IFLDT 286_ IVPKY 291_ EVNGV 296_ KPPIG 301_ QRTRL 306_ SKGDI 311_ AQARK 316_ LYKCP 321_ ACGET 326_ LQDST 331_ GNFSS 336_ PEYPN 341_ GYSAH 346_ MHCVW 351_ RISVT 356_ PGEKI 361_ ILNFT 366_ SLDLY 371_ RSRLC 376_ WYDYV 381_ EVRDG 386_ FWRKA 391_ PLRGR 396_ FCGSK 401_ LPEPI 406_ VSTDS 411_ RLWVE 416_ FRSSS 421_ NWVGK 426_ GFFAV 431_ YEAIC 436_ GGDVK 441_ KDYGH 446_ IQSPN 451_ YPDDY 456_ RPSKV 461_ CIWRI 466_ QVSEG 471_ FHVGL 476_ TFQSF 481_ EIERH 486_ DSCAY 491_ DYLEV 496_ RDGHS 501_ ESSTL 506_ IGRYC 511_ GYEKP 516_ DDIKS 521_ TSSRL 526_ WLKFV 531_ SDGSI 536_ NKAGF 541_ AVNFF 546_ KEVDE 551_ CSRPN 556_ RGGCE 561_ QRCLN 566_ TLGSY 571_ KCSCD 576_ PGYEL 581_ APDKR 586_ RCEAA 591_ CGGFL 596_ TKLNG 601_ SITSP 606_ GWPKE 611_ YPPNK 616_ NCIWQ 621_ LVAPT 626_ QYRIS 631_ LQFDF 636_ FETEG 641_ NDVCK 646_ YDFVE 651_ VRSGL 656_ TADSK 661_ LHGKF 666_ CGSEK 671_ PEVIT 676_ SQYNN 681_ MRVEF 686_ KSDNT 691_ VSKKG 696_ FKAHF 701_ FSDKD 706_ ECSKD 711_ NGGCQ 716_ QDCVN 721_ TFGSY 726_ ECQCR 731_ SGFVL 736_ HDNKH 741_ DCKEA 746_ GCDHK 751_ VTSTS 756_ GTITS 761_ PNWPD 766_ KYPSK 771_ KECTW 776_ AISST 781_ PGHRV 786_ KLTFM 791_ EMDIE 796_ SQPEC 801_ AYDHL 806_ EVFDG 811_ RDAKA 816_ PVLGR 821_ FCGSK 826_ KPEPV 831_ LATGS 836_ RMFLR 841_ FYSDN 846_ SVQRK 851_ GFQAS 856_ HATEC 861_ GGQVR 866_ ADVKT 871_ KDLYS 876_ HAQFG 881_ DNNYP 886_ GGVDC 891_ EWVIV 896_ AEEGY 901_ GVELV 906_ FQTFE 911_ VEEET 916_ DCGYD 921_ YMELF 926_ DGYDS 931_ TAPRL 936_ GRYCG 941_ SGPPE 946_ EVYSA 951_ GDSVL 956_ VKFHS 961_ DDTIT 966_ KKGFH 971_ LRYTS 976_ TKFQD 981_TLHSR
1: Metalloprotease that plays key roles in regulating the formation of the extracellular matrix (ECM) via processing of various precursor proteins into mature functional enzymes or structural proteins (PubMed:33206546). Thereby participates in several developmental and physiological processes such as cartilage and bone formation, muscle growth and homeostasis, wound healing and tissue repair (PubMed:32636307, PubMed:33169406). Roles in ECM formation include cleavage of the C-terminal propeptides from procollagens such as procollagen I, II and III or the proteolytic activation of the enzyme lysyl oxidase LOX, necessary to formation of covalent cross-links in collagen and elastic fibers (PubMed:31152061, PubMed:33206546). Additional substrates include matricellular thrombospondin-1/THBS1 whose cleavage leads to cell adhesion disruption and TGF-beta activation (PubMed:32636307)
2: Plays an important role in bone repair by acting as a coactivator of BMP7