Cytochrome b-245 light chain (Cytochrome b(558) alpha chain) (Cytochrome b558 subunit alpha) (Neutrophil cytochrome b 22 kDa polypeptide) (Superoxide-generating NADPH oxidase light chain subunit) (p22 phagocyte B-cytochrome) (p22-phox) (p22phox)
1_MGQIE 6_ WAMWA 11_ NEQAL 16_ ASGLI 21_ LITGG 26_ IVATA 31_ GRFTQ 36_ WYFGA 41_ YSIVA 46_ GVFVC 51_ LLEYP 56_ RGKRK 61_ KGSTM 66_ ERWGQ 71_ KYMTA 76_ VVKLF 81_ GPFTR 86_ NYYVR 91_ AVLHL 96_ LLSVP 101_ AGFLL 106_ ATILG 111_ TACLA 116_ IASGI 121_ YLLAA 126_ VRGEQ 131_ WTPIE 136_ PKPRE 141_ RPQIG 146_ GTIKQ 151_ PPSNP 156_ PPRPP 161_ AEARK 166_ KPSEE 171_ EAAVA 176_ AGGPP 181_ GGPQV 186_NPIPV
1: Subunit of NADPH oxidase complexes that is required for the NADPH oxidase activity that generates, in various cell types, superoxide from molecular oxygen utilizing NADPH as an electron donor (PubMed:15824103, PubMed:17140397, PubMed:38355798). Subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)) (PubMed:38355798). In the activated complex, electrons are first transferred from NADPH to flavin adenine dinucleotide (FAD) and subsequently transferred via two heme molecules to molecular oxygen, producing superoxide through an outer-sphere reaction (PubMed:38355798). Activation of the NADPH oxidase complex is initiated by the assembly of cytosolic subunits of the NADPH oxidase complex with the core NADPH oxidase complex to form a complex at the plasma membrane or phagosomal membrane (PubMed:38355798). This activation process is initiated by phosphorylation dependent binding of the cytosolic NCF1/p47-phox subunit to the C-terminus of CYBA/p22-phox (PubMed:19948736). Aassociates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide (PubMed:15824103, PubMed:17140397)